Product References
Decreased immunoglobulin G in brain regions of elder female APOE4-TR mice accompany with Aβ accumulation.
Immunity & ageing : I & A
Zhang L,Xu J,Gao J,Chen P,Yin M,Zhao W
14-0051-82 was used in Flow Cytometry to determine the alterations of IgG, CD19, and Aβ in various brain regions of uninfected male and female APOE3- and APOE4-TR mice at the age of 3 and 10 months to elucidate impacts of AD risk factors on alterations of brain IgG.
Thu Mar 31 00:00:00 EDT 2022
The Influence of B Cell Depletion Therapy on Naturally Acquired Immunity to Streptococcus pneumoniae.
Frontiers in immunology
Ercoli G,Ramos-Sevillano E,Nakajima R,de Assis RR,Jasinskas A,Goldblatt D,Felgner P,Weckbecker G,Brown J
Published figure using CD5 monoclonal antibody (Product # 14-0051-82) in Flow Cytometry
Tue Jun 22 00:00:00 EDT 2021
Identification of Distinct Unmutated Chronic Lymphocytic Leukemia Subsets in Mice Based on Their T Cell Dependency.
Frontiers in immunology
Pal Singh S,de Bruijn MJW,de Almeida MP,Meijers RWJ,Nitschke L,Langerak AW,Pillai SY,Stadhouders R,Hendriks RW
14-0051 was used in Flow cytometry/Cell sorting to provide evidence for two distinct unmutated CLL subsets with a specific transcriptional signature: one is T cell-independent and B-1 cell-derived while the other arises upon antigen stimulation in the context of T-cell help.
Mon Sep 30 00:00:00 EDT 2019
Antigen-presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria.
The Journal of experimental medicine
Melo-Gonzalez F,Kammoun H,Evren E,Dutton EE,Papadopoulou M,Bradford BM,Tanes C,Fardus-Reid F,Swann JR,Bittinger K,Mabbott NA,Vallance BA,Willinger T,Withers DR,Hepworth MR
14-0051-82 was used in Flow Cytometry to study the mechanisms that modulate the magnitude and quality of T cell-dependent IgA responses.
Mon Apr 01 00:00:00 EDT 2019
Inhibition of T cell activation and function by the adaptor protein CIN85.
Science signaling
Kong MS,Hashimoto-Tane A,Kawashima Y,Sakuma M,Yokosuka T,Kometani K,Onishi R,Carpino N,Ohara O,Kurosaki T,Phua KK,Saito T
14-0051-82 was used in Flow Cytometry to show that CIN85 (Cbl-interacting protein of 85 kDa) limited T cell responses to T cell receptor stimulation.
Tue Feb 05 00:00:00 EST 2019
Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus.
eLife
Moretti FA,Klapproth S,Ruppert R,Margraf A,Weber J,Pick R,Scheiermann C,Sperandio M,Fässler R,Moser M
Published figure using CD5 monoclonal antibody (Product # 14-0051-82) in Flow Cytometry
Thu Sep 06 00:00:00 EDT 2018
Bruton's Tyrosine Kinase Is Not Essential for B Cell Survival beyond Early Developmental Stages.
Journal of immunology (Baltimore, Md. : 1950)
Nyhoff LE,Clark ES,Barron BL,Bonami RH,Khan WN,Kendall PL
14-0051 was used in Flow cytometry/Cell sorting to raise the possibility that Btk may also be expendable for survival of mature human B cells, therefore requiring prolonged dosing to be effective, and that success of BTK inhibitors may depend in part on off-target effects.
Sun Apr 01 00:00:00 EDT 2018
Host Tumor Suppressor p18INK4c Functions as a Potent Cell-Intrinsic Inhibitor of Murine Gammaherpesvirus 68 Reactivation and Pathogenesis.
Journal of virology
Niemeyer BF,Oko LM,Medina EM,Oldenburg DG,White DW,Cool CD,Clambey ET,van Dyk LF
Published figure using CD5 monoclonal antibody (Product # 14-0051-82) in Flow Cytometry
Thu Mar 15 00:00:00 EDT 2018
Naïve helper T cells with high CD5 expression have increased calcium signaling.
PloS one
Freitas CMT,Hamblin GJ,Raymond CM,Weber KS
Published figure using CD5 monoclonal antibody (Product # 14-0051-82) in Flow Cytometry
Tue Sep 26 00:00:00 EDT 2017
CTCF-Mediated Enhancer-Promoter Interaction Is a Critical Regulator of Cell-to-Cell Variation of Gene Expression.
Molecular cell
Ren G,Jin W,Cui K,Rodrigez J,Hu G,Zhang Z,Larson DR,Zhao K
Published figure using CD5 monoclonal antibody (Product # 14-0051-82) in Flow Cytometry
Thu Sep 21 00:00:00 EDT 2017
Human and Mouse Hematopoietic Stem Cells Are a Depot for Dormant Mycobacterium tuberculosis.
PloS one
Tornack J,Reece ST,Bauer WM,Vogelzang A,Bandermann S,Zedler U,Stingl G,Kaufmann SH,Melchers F
14-0051-82 was used in Flow Cytometry to conclude that LT-pHSCs, together with MSCs of Mtb-infected humans and mice serve as a hitherto unappreciated quiescent cellular depot for Mtb during latent TB infection.
Tue Sep 05 00:00:00 EDT 2017
CD73 regulates anti-inflammatory signaling between apoptotic cells and endotoxin-conditioned tissue macrophages.
Cell death and differentiation
Murphy PS,Wang J,Bhagwat SP,Munger JC,Janssen WJ,Wright TW,Elliott MR
14-0051 was used in Flow cytometry/Cell sorting to show that, in RAW264.7 cells, ectopic expression of both A2a and CD73 was required for TNF suppression by apoptotic cells.
Wed Mar 01 00:00:00 EST 2017
Blood Stem Cell Activity Is Arrested by Th1-Mediated Injury Preventing Engraftment following Nonmyeloablative Conditioning.
Journal of immunology (Baltimore, Md. : 1950)
Müller AM,Florek M,Kohrt HE,Küpper NJ,Filatenkov A,Linderman JA,Hadeiba H,Negrin RS,Shizuru JA
14-0051 was used in Flow cytometry/Cell sorting to shed new light on the effects of CD4+ T cells on HSC biology.
Tue Nov 15 00:00:00 EST 2016
Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal.
Nature cell biology
Pietras EM,Mirantes-Barbeito C,Fong S,Loeffler D,Kovtonyuk LV,Zhang S,Lakshminarasimhan R,Chin CP,Techner JM,Will B,Nerlov C,Steidl U,Manz MG,Schroeder T,Passegué E
14-0051 was used in Flow cytometry/Cell sorting to identify a critical regulatory circuit that tailors HSC responses to acute needs, and is likely to underlie deregulated blood homeostasis in chronic inflammation conditions.
Wed Jun 01 00:00:00 EDT 2016
Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation.
Nature immunology
Monticelli LA,Buck MD,Flamar AL,Saenz SA,Tait Wojno ED,Yudanin NA,Osborne LC,Hepworth MR,Tran SV,Rodewald HR,Shah H,Cross JR,Diamond JM,Cantu E,Christie JD,Pearce EL,Artis D
14-0051 was used in Flow cytometry/Cell sorting to identify Arg1 as a key regulator of group 2 innate lymphoid cell bioenergetics that control proliferative capacity and pro-inflammatory functions.
Wed Jun 01 00:00:00 EDT 2016
NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells.
Nature communications
Alrefai H,Muhammad K,Rudolf R,Pham DA,Klein-Hessling S,Patra AK,Avots A,Bukur V,Sahin U,Tenzer S,Goebeler M,Kerstan A,Serfling E
Published figure using CD5 monoclonal antibody (Product # 14-0051-82) in Flow Cytometry
Wed May 25 00:00:00 EDT 2016
CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation.
Nature communications
Cao W,Guo J,Wen X,Miao L,Lin F,Xu G,Ma R,Yin S,Hui Z,Chen T,Guo S,Chen W,Huang Y,Liu Y,Wang J,Wei L,Wang L
14-0051 was used in Flow cytometry/Cell sorting to investigate whether the CpG-binding protein Cxxc1 plays a role in thymocyte development.
Mon May 23 00:00:00 EDT 2016
Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint.
PloS one
Tamehiro N,Oda H,Shirai M,Suzuki H
14-0051 was used in Flow cytometry/Cell sorting to indicate that an excess amount of RhoH is able to initiate pre-TCR signalling in the absence of pre-TCR complexes.
Mon Apr 25 00:00:00 EDT 2016
Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells.
Cancer research
Tang CH,Zundell JA,Ranatunga S,Lin C,Nefedova Y,Del Valle JR,Hu CC
14-0051 was used in Flow cytometry/Cell sorting to investigate the role of STING in inducing apoptosis in malignant B cells.
Fri Apr 15 00:00:00 EDT 2016
LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors.
The Journal of clinical investigation
Cheng Y,Chikwava K,Wu C,Zhang H,Bhagat A,Pei D,Choi JK,Tong W
14-0051 was used in Flow cytometry/Cell sorting to investigate how LNK regulates normal B cell development or promotes leukemogenesis.
Fri Apr 01 00:00:00 EDT 2016
Protective Role for B-1b B Cells and IgM in Obesity-Associated Inflammation, Glucose Intolerance, and Insulin Resistance.
Arteriosclerosis, thrombosis, and vascular biology
Harmon DB,Srikakulapu P,Kaplan JL,Oldham SN,McSkimming C,Garmey JC,Perry HM,Kirby JL,Prohaska TA,Gonen A,Hallowell P,Schirmer B,Tsimikas S,Taylor AM,Witztum JL,McNamara CA
14-0051 was used in Flow cytometry/Cell sorting to investigate the role of B-cell functions in obesity-induced metabolic dysfunction.
Fri Apr 01 00:00:00 EDT 2016
Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis.
Mucosal immunology
Mohapatra A,Van Dyken SJ,Schneider C,Nussbaum JC,Liang HE,Locksley RM
14-0051 was used in Flow cytometry/Cell sorting to study how ILC2s link alveolar function to regulation of airway flow, revealing a key interaction between resident lymphoid and structural cells that might underlie similar organisational hierarchies in other organs.
Fri Jan 01 00:00:00 EST 2016
The BAFF receptor TACI controls IL-10 production by regulatory B cells and CLL B cells.
Leukemia
Saulep-Easton D,Vincent FB,Quah PS,Wei A,Ting SB,Croce CM,Tam C,Mackay F
14-0051 was used in Flow cytometry/Cell sorting to uncover a major targetable pathway important for the generation of regulatory B cells that is detrimental to immunity in chronic lymphocytic leukemia.
Fri Jan 01 00:00:00 EST 2016
B cell Rab7 mediates induction of activation-induced cytidine deaminase expression and class-switching in T-dependent and T-independent antibody responses.
Journal of immunology (Baltimore, Md. : 1950)
Pone EJ,Lam T,Lou Z,Wang R,Chen Y,Liu D,Edinger AL,Xu Z,Casali P
Published figure using CD5 monoclonal antibody (Product # 14-0051-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2015
The atypical chemokine receptor ACKR2 suppresses Th17 responses to protein autoantigens.
Immunology and cell biology
Hansell CA,MacLellan LM,Oldham RS,Doonan J,Chapple KJ,Anderson EJ,Linington C,McInnes IB,Nibbs RJ,Goodyear CS
14-0051 was used in Flow cytometry/Cell sorting to investigate the role of ACKR2 in autoimmunity, showing that it suppresses Th17 responses to protein autoantigens.
Sun Feb 01 00:00:00 EST 2015
CCR7-dependent trafficking of RORγ⁺ ILCs creates a unique microenvironment within mucosal draining lymph nodes.
Nature communications
Mackley EC,Houston S,Marriott CL,Halford EE,Lucas B,Cerovic V,Filbey KJ,Maizels RM,Hepworth MR,Sonnenberg GF,Milling S,Withers DR
14-0051 was used in Flow cytometry/Cell sorting to investigate whether group 3 innate lymphoid cells migrate from their mucosal and peripheral sites to local draining secondary lymphoid tissues.
Fri Jan 09 00:00:00 EST 2015
In vivo functional mapping of the conserved protein domains within murine Themis1.
Immunology and cell biology
Zvezdova E,Lee J,El-Khoury D,Barr V,Akpan I,Samelson L,Love PE
14-0051 was used in Flow cytometry/Cell sorting to investigate the functional importance of different Themis1 domains.
Mon Sep 01 00:00:00 EDT 2014
Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses.
eLife
Chiba S,Ikushima H,Ueki H,Yanai H,Kimura Y,Hangai S,Nishio J,Negishi H,Tamura T,Saijo S,Iwakura Y,Taniguchi T
14-0051 was used in Flow cytometry/Cell sorting to show that recognition of tumor cells by Dectin-1 receptors leads to activation of the tumoricidal activity of NK cells.
Fri Aug 22 00:00:00 EDT 2014
In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice.
Blood
Derderian SC,Togarrati PP,King C,Moradi PW,Reynaud D,Czechowicz A,Weissman IL,MacKenzie TC
14-0051 was used in Flow cytometry/Cell sorting to develop a successful foetal conditioning strategy associated with minimal toxicity.
Thu Aug 07 00:00:00 EDT 2014
Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival.
The Journal of clinical investigation
Tang CH,Ranatunga S,Kriss CL,Cubitt CL,Tao J,Pinilla-Ibarz JA,Del Valle JR,Hu CC
14-0051 was used in Flow cytometry/Cell sorting to investigate the role of ER stress response in chronic lymphocytic leukaemia, showing that inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival.
Sun Jun 01 00:00:00 EDT 2014
B cell-specific loss of Lyn kinase leads to autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Lamagna C,Hu Y,DeFranco AL,Lowell CA
14-0051-82 was used in Flow Cytometry to demonstrate that B cell-intrinsic Lyn-dependent signalling pathways regulate B cell homeostasis and activation.
Sat Feb 01 00:00:00 EST 2014
Unique features of naive CD8+ T cell activation by IL-2.
Journal of immunology (Baltimore, Md. : 1950)
Cho JH,Kim HO,Kim KS,Yang DH,Surh CD,Sprent J
14-0051 was used in in vitro experiments to demonstrate that IL-2 elicits a unique signaling pattern associated with strong lymphocyte-specific protein tyrosine kinase/JAK3-dependent activation of the PI3K/AKT pathway.
Sun Dec 01 00:00:00 EST 2013
A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing.
Nature
Florian MC,Nattamai KJ,Dörr K,Marka G,Uberle B,Vas V,Eckl C,Andrä I,Schiemann M,Oostendorp RA,Scharffetter-Kochanek K,Kestler HA,Zheng Y,Geiger H
14-0051 was used in Immunocytochemistry to evaluate the role of Wnt signalling in the ageing of haematopoietic stem cells in mice.
Thu Nov 21 00:00:00 EST 2013
A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing.
Nature
Florian MC,Nattamai KJ,Dörr K,Marka G,Uberle B,Vas V,Eckl C,Andrä I,Schiemann M,Oostendorp RA,Scharffetter-Kochanek K,Kestler HA,Zheng Y,Geiger H
14-0051 was used in Immunocytochemistry to evaluate the role of Wnt signalling in the ageing of haematopoietic stem cells in mice.
Thu Nov 21 00:00:00 EST 2013
Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation.
eLife
Kerenyi MA,Shao Z,Hsu YJ,Guo G,Luc S,O'Brien K,Fujiwara Y,Peng C,Nguyen M,Orkin SH
14-0051 was used in Flow cytometry/Cell sorting to study how Lsd1-mediated concurrent repression of enhancer and promoter activity of stem and progenitor cell genes is a pivotal epigenetic mechanism required for proper hematopoietic maturation.
Tue Jun 18 00:00:00 EDT 2013
Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells.
Nature immunology
Roediger B,Kyle R,Yip KH,Sumaria N,Guy TV,Kim BS,Mitchell AJ,Tay SS,Jain R,Forbes-Blom E,Chen X,Tong PL,Bolton HA,Artis D,Paul WE,Fazekas de St Groth B,Grimbaldeston MA,Le Gros G,Weninger W
14-0051 was used in Flow cytometry/Cell sorting to report the identification in normal mouse dermis of an abundant, phenotypically unique group 2 innate lymphoid cell subset that depended on interleukin 7 and constitutively produced IL-13.
Sat Jun 01 00:00:00 EDT 2013
Natural killer cells are required for extramedullary hematopoiesis following murine cytomegalovirus infection.
Cell host & microbe
Jordan S,Ruzsics Z,Mitrović M,Baranek T,Arapović J,Krmpotić A,Vivier E,Dalod M,Jonjić S,Dölken L,Koszinowski UH
14-0051 was used in Flow cytometry/Cell sorting to investigate the underlying mechanisms of extramedullary hematopoiesis.
Wed May 15 00:00:00 EDT 2013
Critical role of SAP in progression and reactivation but not maintenance of T cell-dependent humoral immunity.
Molecular and cellular biology
Zhong MC,Veillette A
14-0051 was used in Flow cytometry/Cell sorting to explore the therapeutic potential of blocking the SLAM-associated protein (SAP) for human autoimmune diseases.
Fri Mar 01 00:00:00 EST 2013
T cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigens.
Immunity
Mandl JN,Monteiro JP,Vrisekoop N,Germain RN
14-0051 was used in Flow cytometry/Cell sorting to provide evidence for a connection between thymic recognition events and foreign antigen-driven T cell responses.
Thu Feb 21 00:00:00 EST 2013
Molecular definition of the identity and activation of natural killer cells.
Nature immunology
Bezman NA,Kim CC,Sun JC,Min-Oo G,Hendricks DW,Kamimura Y,Best JA,Goldrath AW,Lanier LL
14-0051 was used in Flow cytometry/Cell sorting to systematically define the transcriptome of mouse natural killer cells in several contexts.
Mon Oct 01 00:00:00 EDT 2012
PIDDosome-independent tumor suppression by Caspase-2.
Cell death and differentiation
Manzl C,Peintner L,Krumschnabel G,Bock F,Labi V,Drach M,Newbold A,Johnstone R,Villunger A
14-0051 was used in Flow cytometry/Cell sorting to investigate the role of PIDD, RIP-1 kinase and Nemo/IKKγ in oncogenesis induced by DNA damage or oncogenic stress in gene-ablated mice.
Mon Oct 01 00:00:00 EDT 2012
Unexpected role for MHC II-peptide complexes in shaping CD8 T-cell expansion and differentiation in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Do JS,Valujskikh A,Vignali DA,Fairchild RL,Min B
14-0051 was used in Flow cytometry/Cell sorting to reveal a previously undefined MHC II-dependent regulation that tunes CD8 T-cell reactivity.
Tue Jul 31 00:00:00 EDT 2012
Anti-CD180 (RP105) activates B cells to rapidly produce polyclonal Ig via a T cell and MyD88-independent pathway.
Journal of immunology (Baltimore, Md. : 1950)
Chaplin JW,Kasahara S,Clark EA,Ledbetter JA
14-0051 was used in Flow cytometry/Cell sorting to study the effect of injection of anti-CD180 mAb into mice on the production of immunoglobulins.
Sat Oct 15 00:00:00 EDT 2011
Rescue of tumor-infiltrating lymphocytes from activation-induced cell death enhances the antitumor CTL response in CD5-deficient mice.
Journal of immunology (Baltimore, Md. : 1950)
Tabbekh M,Franciszkiewicz K,Haouas H,Lécluse Y,Benihoud K,Raman C,Mami-Chouaib F
14-0051-81 was used in Flow Cytometry to compare the T cell response to the B16F10 melanoma engrafted into CD5-deficient and wild-type C57BL/6 mice.
Fri Jul 01 00:00:00 EDT 2011
L2pB1: a new player in autoimmunity.
Molecular immunology
Zhong X,Rothstein TL
14-0051 was used in Flow cytometry/Cell sorting to review the features of PD-L2 positive B1 cells and their contribution to autoimmunity.
Wed Jun 01 00:00:00 EDT 2011
B-cell homeostasis requires complementary CD22 and BLyS/BR3 survival signals.
International immunology
Smith SH,Haas KM,Poe JC,Yanaba K,Ward CD,Migone TS,Tedder TF
14-0051 was used in Flow cytometry/Cell sorting to support a model whereby B cells must integrate varied signals, including those from the BLyS- BR3 axis, CD22-ligand binding and antigen-receptor-mediated tonic signaling for their homeostatic maintenance in vivo.
Sun Aug 01 00:00:00 EDT 2010
Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad.
Blood
Frenzel A,Labi V,Chmelewskij W,Ploner C,Geley S,Fiegl H,Tzankov A,Villunger A
14-0051 was used in Flow cytometry/Cell sorting to demonstrate the potential of BH3-only proapoptotic Bcl-2 family members to regulate excessive lymphocyte proliferation.
Thu Feb 04 00:00:00 EST 2010
Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance.
Journal of immunology (Baltimore, Md. : 1950)
Gross AJ,Lyandres JR,Panigrahi AK,Prak ET,DeFranco AL
14-0051 was used in Flow cytometry/Cell sorting to indicate that the Lyn-CD22 inhibitory pathway largely becomes operational as B cells mature, and is critical for the maintenance of tolerance in the B cell compartment.
Fri May 01 00:00:00 EDT 2009
Oncogenic Kras initiates leukemia in hematopoietic stem cells.
PLoS biology
Sabnis AJ,Cheung LS,Dail M,Kang HC,Santaguida M,Hermiston ML,Passegué E,Shannon K,Braun BS
14-0051 was used in Flow cytometry/Cell sorting to conclude that MPD-initiating activity is restricted to the HSC compartment in Kras(G12D) mice.
Tue Mar 17 00:00:00 EDT 2009
Murine isolated lymphoid follicles contain follicular B lymphocytes with a mucosal phenotype.
American journal of physiology. Gastrointestinal and liver physiology
Wang C,McDonald KG,McDonough JS,Newberry RD
14-0051 was used in Flow cytometry/Cell sorting to indicate that murine ILFs contain a polyclonal population of follicular B-2 B lymphocytes with a phenotype similar to PP B lymphocytes.
Sun Oct 01 00:00:00 EDT 2006
