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Invitrogen

CD51/CD61 Monoclonal Antibody (23C6)

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View all (13) CD51/CD61 antibodies

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CD51/CD61 Monoclonal Antibody (23C6)

Product Details

MA1-33578

Applications
Tested Dilution
Publications

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent
-

Immunocytochemistry (ICC/IF)

Assay-dependent
View 1 publication 1 publication

Flow Cytometry (Flow)

1:40-1:80
-

Immunoprecipitation (IP)

Assay-dependent
-

Functional Assay (Functional)

Assay-dependent
-

Miscellaneous PubMed (Misc)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Chicken, Human, Rat

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

23C6

Immunogen

Osteoclasts from osteoclastomas.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1955362

Product Specific Information

For flow cytometry use 10 µL of the suggested working dilution to label 10^6 cells in 100 µL.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

CD51 and CD61 molecules (alpha V and beta 3 integrins) form a complex. This complex binds vitronection at the RGD sequence and can also bind fibrinogen, von Willebrand factor, thrombospondin, fibronectin, osteopontin and collagen. Reacts with osteoclasts, placenta, melanoma cell lines and weakly with platelets.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: antigen CD61; antigen identified by monoclonal antibody L230; CD51; CD61; Dnmt3l-ps1 pseudogene; glycoprotein IIIa precursor; GPIIIa; integrin alpha-5 beta-3; Integrin alpha-V; integrin alphaVbeta3; Integrin beta; integrin beta 3; integrin beta 3 (Cd61); integrin beta chain, beta 3; Integrin beta-3; integrin beta-3 subunit; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); plate glycoprotein IIIa (GPIIIa); Platelet membrane glycoprotein IIIa; unnamed protein product; vitronectin alpha subunit precursor; Vitronectin receptor; vitronectin receptor alpha subunit; Vitronectin receptor subunit alpha

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Gene Aliases: BDPLT16; BDPLT2; BDPLT24; CD51; CD61; GP3A; GPIIIa; GT; GT2; integrin; ITGAV; ITGB3; MSK8; VNRA; VTNR

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UniProt ID: (Chicken) P26008, (Human) P06756, (Human) P05106, (Rat) Q8R2H2

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Entrez Gene ID: (Chicken) 396420, (Human) 3685, (Chicken) 374209, (Human) 3690, (Rat) 296456, (Rat) 29302

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Function(s)
metal ion binding virus receptor activity opsonin binding fibronectin binding protease binding protein kinase C binding receptor binding integrin binding protein binding coreceptor activity fibroblast growth factor binding C-X3-C chemokine binding insulin-like growth factor I binding signaling receptor activity neuregulin binding transforming growth factor beta binding extracellular matrix binding extracellular matrix protein binding protein disulfide isomerase activity platelet-derived growth factor receptor binding enzyme binding identical protein binding vascular endothelial growth factor receptor 2 binding cell adhesion molecule binding fibrinogen binding voltage-gated calcium channel activity peptide binding protein heterodimerization activity integrin
Process(es)
angiogenesis integrin-mediated signaling pathway cell adhesion mediated by integrin regulation of transforming growth factor beta activation blood vessel development vasculogenesis formation of primary germ layer cell adhesion cell-matrix adhesion positive regulation of cytosolic calcium ion concentration positive regulation of cell proliferation tissue development negative regulation of macrophage derived foam cell differentiation negative regulation of lipid storage negative regulation of low-density lipoprotein particle clearance cell migration positive regulation of cell migration cell-substrate adhesion negative regulation of lipid transport positive regulation of osteoblast proliferation heterotypic cell-cell adhesion substrate adhesion-dependent cell spreading wound healing, spreading of epidermal cells endodermal cell differentiation apolipoprotein A-I-mediated signaling pathway apoptotic cell clearance positive regulation of cell adhesion viral entry into host cell negative regulation of lipoprotein metabolic process regulation of phagocytosis negative chemotaxis positive regulation of small GTPase mediated signal transduction ERK1 and ERK2 cascade calcium ion transmembrane transport transforming growth factor beta production entry into host cell by a symbiont-containing vacuole extrinsic apoptotic signaling pathway in absence of ligand cell-cell adhesion positive regulation of intracellular signal transduction negative regulation of entry of bacterium into host cell negative regulation of extrinsic apoptotic signaling pathway positive regulation of endothelial cell proliferation positive regulation of cell-matrix adhesion positive regulation of leukocyte migration cell-substrate junction assembly embryo implantation blood coagulation regulation of G-protein coupled receptor protein signaling pathway positive regulation of endothelial cell migration positive regulation of gene expression positive regulation of fibroblast migration response to activity smooth muscle cell migration positive regulation of smooth muscle cell migration platelet activation positive regulation of vascular endothelial growth factor receptor signaling pathway regulation of protein localization regulation of actin cytoskeleton organization positive regulation of cell adhesion mediated by integrin tube development response to platelet-derived growth factor cellular response to platelet-derived growth factor stimulus wound healing regulation of bone resorption positive regulation of angiogenesis positive regulation of bone resorption platelet-derived growth factor receptor signaling pathway positive regulation of fibroblast proliferation mesodermal cell differentiation positive regulation of smooth muscle cell proliferation regulation of developmental process regulation of transport regulation of release of sequestered calcium ion into cytosol regulation of serotonin uptake angiogenesis involved in wound healing regulation of biological quality positive regulation of ERK1 and ERK2 cascade platelet aggregation cellular response to mechanical stimulus cellular response to xenobiotic stimulus positive regulation of glomerular mesangial cell proliferation blood coagulation, fibrin clot formation maintenance of postsynaptic specialization structure regulation of postsynaptic neurotransmitter receptor internalization regulation of postsynaptic neurotransmitter receptor diffusion trapping positive regulation of substrate adhesion-dependent cell spreading positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway positive regulation of vascular endothelial growth factor signaling pathway regulation of trophoblast cell migration regulation of extracellular matrix organization cellular response to insulin-like growth factor stimulus negative regulation of endothelial cell apoptotic process positive regulation of T cell migration cellular calcium ion homeostasis cell growth positive regulation of MAPK cascade negative regulation of low-density lipoprotein particle receptor biosynthetic process regulation of apoptotic cell clearance protein folding response to radiation regulation of cell migration activation of protein kinase activity cellular response to drug positive regulation of peptidyl-tyrosine phosphorylation negative regulation of cell death
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