|Tested species reactivity||Human|
|Published species reactivity||Virus, Human, Mouse, Not Applicable|
|Host / Isotype||Mouse / IgG1|
|Immunogen||SCLC membrane preparation|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|Immunohistochemistry (IHC)||Assay Dependent|
|Immunoprecipitation (IP)||2-5 µg|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
NCAM, as a member of the immunoglobulin superfamily of adhesion molecules is characterized by several immunoglobulin (Ig)-like domains. The extracellular part of NCAM consists of five of these Ig domains and two fibronectin type III homology regions. NCAM is encoded by a single copy gene composed of 26 exons. However, at least 20-30 distinct isoforms can be generated by alternative splicing and by posttranslational modifications, such as sialylation. During sialylation, polysialic acid (PSA) carbohydrates are attached to the extracellular part of NCAM. Through its extracellular region, NCAM mediates homophilic interactions. In addition, NCAM can also undergo heterophilic interactions by binding extracellular matrix components, such as laminin, or other cell adhesion molecules, such as integrins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Not Applicable||Not Cited||
Variable Expression of Neural Cell Adhesion Molecule Isoforms in Renal Tissue: Possible Role in Incipient Renal Fibrosis.
07-5603 was used in immunohistochemistry - paraffin section to learn the possible role of incipient renal fibrosis by variable expression of neural cell adhesion molecule isoforms in renal tissue
|Markovi¿-Lipkovski J,¿ivoti¿ M,Müller CA,Tampe B,¿irovi¿ S,Vje¿tica J,Tomanovi¿ N,Zeisberg M,Müller GA||PloS one (10:null)||2015|
A case of (123)I-MIBG scintigram-negative functioning pheochromocytoma: immunohistochemical and molecular analysis with review of literature.
07-5603 was used in immunohistochemistry - paraffin section to present the case of a (123)I-MIBG negative pheochromocytoma
|Kurisaki-Arakawa A,Saito T,Takahashi M,Mitani K,Yao T||International journal of clinical and experimental pathology (7:4438)||2014|
|Not Applicable||Not Cited||
Extraosseous (extramedullary) plasmacytomas: a clinicopathologic and immunophenotypic study of 32 Chinese cases.
07-5603 was used in immunohistochemistry - paraffin section to determine the clinicopathologic features and diagnosis of extraosseous plasmacytomas
|Zuo Z,Tang Y,Bi CF,Zhang WY,Zhao S,Wang XQ,Yang QP,Zou LQ,Liu WP||Diagnostic pathology (6:null)||2011|
Neuronal Subtype and Satellite Cell Tropism Are Determinants of Varicella-Zoster Virus Virulence in Human Dorsal Root Ganglia Xenografts In Vivo.
07-5603 was used in immunohistochemistry to characterize human dorsal root ganglia xenografts in vivo for satellite cell tropism and neuronal subtype which are determinants of varicella-zoster virus virulence
|Zerboni L,Arvin A||PLoS pathogens (11:null)||2015|
A Case of Distal Epithelioid Sarcoma of the Thumb Expressing Podoplanin, TLE1 and Ca 125.
07-5603 was used in immunohistochemistry to characterize the case of a distal epithelioid sarcoma arising in the thumb of a 14-year-old girl
|Karagkounis G,Argyrakos T,Charkiolakis G,Castana O,Rontogianni D||Case reports in pathology (2013:null)||2013|
|Not Applicable||Not Cited||
Subcutaneous panniculitis-like T-cell lymphoma: a clinical and pathologic study of 14 korean patients.
07-5603 was used in immunohistochemistry to study subcutaneous panniculitis-like T-cell lymphomas in Korean patients
|Lee DW,Yang JH,Lee SM,Won CH,Chang S,Lee MW,Choi JH,Moon KC||Annals of dermatology (23:329)||2011|
|Varicella-zoster virus infection of human neural cells in vivo.||Baiker A,Fabel K,Cozzio A,Zerboni L,Fabel K,Sommer M,Uchida N,He D,Weissman I,Arvin AM||Proceedings of the National Academy of Sciences of the United States of America (101:10792)||2004|
||Simian virus 40 sequences in malignant lymphomas in Japan.||Nakatsuka S,Liu A,Dong Z,Nomura S,Takakuwa T,Miyazato H,Aozasa K||Cancer research (63:7606)||2003|
Arterial flow regulator enables transplantation and growth of human fetal kidneys in rats.
07-5603 was used in immunohistochemistry to establish a new method to transplant human fetal kidneys into adult rats
|Chang NK,Gu J,Gu S,Osorio RW,Concepcion W,Gu E||American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (15:1692)||2015|
CD30(+) extranodal natural killer/T-cell lymphoma mimicking phlegmonous myositis: A case report.
07-5603 was used in immunohistochemistry (paraffin) to report on a case of CD30-positive extranodal natural killer/T-cell lymphoma.
|Yang YJ,Li YX,Liu YB,Yang M,Liu K||Oncology letters (7:1419)||2014|
Serous effusion cytology of extranodal natural killer/T-cell lymphoma.
07-5603 was used in flow cytometry to characterize extranodal natural killer/T-cell lymphoma, nasal type using patient samples.
|Su XY,Huang J,Jiang Y,Tang Y,Li GD,Liu WP||Cytopathology : official journal of the British Society for Clinical Cytology (23:96)||2012|
Goblet cell carcinoid of the appendix: a clinicopathological and immunohistochemical study of 26 cases from southwest china.
07-5603 was used in immunohistochemistry - paraffin section to report the clinicopathological and immunohistochemical features of goblet cell carcinoid
|International journal of surgical pathology (18:488)||2010|
|Human||1:200||Uterine NK cells regulate endometrial bleeding in women and are suppressed by the progesterone receptor modulator asoprisnil.||Wilkens J,Male V,Ghazal P,Forster T,Gibson DA,Williams AR,Brito-Mutunayagam SL,Craigon M,Lourenco P,Cameron IT,Chwalisz K,Moffett A,Critchley HO||Journal of immunology (Baltimore, Md. : 1950) (191:2226)||2013|
|Human||Not Cited||Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma.||Doubrovina ES,Doubrovin MM,Vider E,Sisson RB,O'Reilly RJ,Dupont B,Vyas YM||Journal of immunology (Baltimore, Md. : 1950) (171:6891)||2003|
|Virus||1:40||Simian virus 40 sequences in malignant lymphomas in Japan.||Nakatsuka S,Liu A,Dong Z,Nomura S,Takakuwa T,Miyazato H,Aozasa K||Cancer research (63:7606)||2003|