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|Tested species reactivity||Human|
|Published species reactivity||Virus, Human, Mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||SCLC membrane preparation|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|Immunohistochemistry (IHC)||Assay Dependent|
|Immunoprecipitation (IP)||2-5 µg|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
NCAM, as a member of the immunoglobulin superfamily of adhesion molecules is characterized by several immunoglobulin (Ig)-like domains. The extracellular part of NCAM consists of five of these Ig domains and two fibronectin type III homology regions. NCAM is encoded by a single copy gene composed of 26 exons. However, at least 20-30 distinct isoforms can be generated by alternative splicing and by posttranslational modifications, such as sialylation. During sialylation, polysialic acid (PSA) carbohydrates are attached to the extracellular part of NCAM. Through its extracellular region, NCAM mediates homophilic interactions. In addition, NCAM can also undergo heterophilic interactions by binding extracellular matrix components, such as laminin, or other cell adhesion molecules, such as integrins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CD30(+) extranodal natural killer/T-cell lymphoma mimicking phlegmonous myositis: A case report.
07-5603 was used in immunohistochemistry (paraffin) to report on a case of CD30-positive extranodal natural killer/T-cell lymphoma.
|Yang YJ,Li YX,Liu YB,Yang M,Liu K||Oncology letters (7:1419)||2014|
|Human||1:200||Uterine NK cells regulate endometrial bleeding in women and are suppressed by the progesterone receptor modulator asoprisnil.||Wilkens J,Male V,Ghazal P,Forster T,Gibson DA,Williams AR,Brito-Mutunayagam SL,Craigon M,Lourenco P,Cameron IT,Chwalisz K,Moffett A,Critchley HO||Journal of immunology (Baltimore, Md. : 1950) (191:2226)||2013|
|Human||Not Cited||Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma.||Doubrovina ES,Doubrovin MM,Vider E,Sisson RB,O'Reilly RJ,Dupont B,Vyas YM||Journal of immunology (Baltimore, Md. : 1950) (171:6891)||2003|
|Virus||1:40||Simian virus 40 sequences in malignant lymphomas in Japan.||Nakatsuka S,Liu A,Dong Z,Nomura S,Takakuwa T,Miyazato H,Aozasa K||Cancer research (63:7606)||2003|
|Mouse||Not Cited||Varicella-zoster virus infection of human neural cells in vivo.||Baiker A,Fabel K,Cozzio A,Zerboni L,Fabel K,Sommer M,Uchida N,He D,Weissman I,Arvin AM||Proceedings of the National Academy of Sciences of the United States of America (101:10792)||2004|
antigen recognized by monoclonal antibody 5.1H11; CD-56; MSK39; NCAM; NCAM1; neural cell adhesion molecule 1; neural cell adhesion molecule, NCAM
CD56; MSK39; NCAM; NCAM1