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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Small cell lung carcinoma.|
|Contains||0.09% sodium azide|
|Storage Conditions||4°C or -20°C if preferred|
|Tested Applications||Dilution *|
|Immunohistochemistry (Frozen) (IHC (F))||1:100-1:200|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100 - 1:200|
|Western Blot (WB)||1:100-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-06801 detects NCAM in human samples.
MA1-06801 has sucessfully been used in Western blotting, immunohistochemistry, and immunocytochemistry procedures.
The MA1-06801 immunogen a membrane preparation of a small cell lung carcinoma.
NCAM, as a member of the immunoglobulin superfamily of adhesion molecules is characterized by several immunoglobulin (Ig)-like domains. The extracellular part of NCAM consists of five of these Ig domains and two fibronectin type III homology regions. NCAM is encoded by a single copy gene composed of 26 exons. However, at least 20-30 distinct isoforms can be generated by alternative splicing and by posttranslational modifications, such as sialylation. During sialylation, polysialic acid (PSA) carbohydrates are attached to the extracellular part of NCAM. Through its extracellular region, NCAM mediates homophilic interactions. In addition, NCAM can also undergo heterophilic interactions by binding extracellular matrix components, such as laminin, or other cell adhesion molecules, such as integrins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Reevaluation and reclassification of resected lung carcinomas originally diagnosed as squamous cell carcinoma using immunohistochemical analysis.
MA1-06801 was used in immunohistochemistry - paraffin section to determine if immunohistochemical analysis can be used to re-classify lung carcinomas that were originally diagnosed as squamous cell carcinoma
|Kadota K,Nitadori J,Rekhtman N,Jones DR,Adusumilli PS,Travis WD||The American journal of surgical pathology (39:1170)||2015|
Role of cd56 and e-cadherin expression in the differential diagnosis of papillary thyroid carcinoma and suspected follicular-patterned lesions of the thyroid: the prognostic importance of e-cadherin.
MA1-06801 was used in immunohistochemistry - paraffin section to discuss how to distinguish follicular variant of PTC from other follicular-patterned lesions of the thyroid.
|Ceyran AB,Şenol S,Şimşek BÇ,Sağıroğlu J,Aydın A||International journal of clinical and experimental pathology (8:3670)||2015|
Immunological significance of the accumulation of autophagy components in oral squamous cell carcinoma.
MA1-06801 was used in immunohistochemistry - paraffin section to study the relationship between autophagy and anti-tumor immune responses using immunohistochemistry
|Sakakura K,Takahashi H,Kaira K,Toyoda M,Oyama T,Chikamatsu K||Cancer science (106:1)||2015|
Pagetoid reticulosis tumor cells with double expression of TCRγδ and TCRαβ: an off-target phenomenon or genuine expression?
MA1-06801 was used in immunohistochemistry to describe the gluteal lesions of a patient with pagetoid reticulosis
|Tomasini D,Niccoli A,Crivelli F||Journal of cutaneous pathology (42:427)||2015|
Primary central nervous system peripheral T-cell lymphoma in a child.
MA1-06801 was used in immunohistochemistry to report on a case of primary central nervous system peripheral T-cell lymphoma in a child
|Gualco G,Wludarski S,Hayashi-Silva L,Medeiros Filho P,Veras G,Bacchi CE||Fetal and pediatric pathology (29:224)||2010|
Atypical carcinoid with prominent mucinous stroma: a hitherto unreported variant of pulmonary neuroendocrine tumor.
MA1-06801 was used in immunohistochemistry to report on a case of atypical carcinoid with prominent mucinous stroma
|Nannini N,Bertolini F,Cavazza A,Casali C,Mengoli MC,Rossi G||Endocrine pathology (21:120)||2010|
Primary plasmacytoma of the cervix in a 21-year-old female patient.
MA1-06801 was used in immunohistochemistry to report on a case of primary plasmacytoma of the cervix
|Schor AP,Moraes MP,Bisson FW,Bisson MA,Luiz OM,Bacchi CE||International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists (29:290)||2010|
EGFR and K-ras mutations along the spectrum of pulmonary epithelial tumors of the lung and elaboration of a combined clinicopathologic and molecular scoring system to predict clinical responsiveness to EGFR inhibitors.
MA1-06801 was used in immunohistochemistry to develop a combined clinicopathologic and molecular scoring system for assessing the tumor responses to EGFR inhibitors
|Sartori G,Cavazza A,Sgambato A,Marchioni A,Barbieri F,Longo L,Bavieri M,Murer B,Meschiari E,Tamberi S,Cadioli A,Luppi F,Migaldi M,Rossi G||American journal of clinical pathology (131:478)||2009|
Composite lymphoma: EBV-positive classic Hodgkin lymphoma and peripheral T-cell lymphoma: a case report.
MA1-06801 was used in immunohistochemistry to report on a case of composite EBV-positive classic Hodgkin lymphoma and peripheral T-cell lymphoma
|Gualco G,Chioato L,Van Den Berg A,Weiss LM,Bacchi CE||Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry (17:72)||2009|
TTF-1, cytokeratin 7, 34betaE12, and CD56/NCAM immunostaining in the subclassification of large cell carcinomas of the lung.
MA1-06801 was used in immunohistochemistry to study the use of a number of immunohistochemical markers for the subclassification of large cell carcinomas of the lung
|Rossi G,Marchioni A,Milani M,Scotti R,Foroni M,Cesinaro A,Longo L,Migaldi M,Cavazza A||American journal of clinical pathology (122:884)||2004|
The prognostic role of c-kit protein expression in resected large cell neuroendocrine carcinoma of the lung.
MA1-06801 was used in immunohistochemistry to study the prognostic value of c-kit protein expression in resected large cell neuroendocrine carcinoma
|Casali C,Stefani A,Rossi G,Migaldi M,Bettelli S,Parise A,Morandi U||The Annals of thoracic surgery (77:247)||2004|
Desmoplastic and spindle cell melanomas express protein markers of the neural crest but not of later committed stages of Schwann cell differentiation.
MA1-06801 was used in immunohistochemistry to investigate the expression of unique protein markers in desmoplastic and spindle cell melanomas
|Huttenbach Y,Prieto VG,Reed JA||Journal of cutaneous pathology (29:562)||2002|
CD30(+) extranodal natural killer/T-cell lymphoma mimicking phlegmonous myositis: A case report.
MA1-06801 was used in immunohistochemistry (paraffin) to report on a case of CD30-positive extranodal natural killer/T-cell lymphoma.
|Yang YJ,Li YX,Liu YB,Yang M,Liu K||Oncology letters (7:1419)||2014|
antigen recognized by monoclonal antibody 5.1H11; CD-56; MSK39; NCAM; NCAM1; neural cell adhesion molecule 1; neural cell adhesion molecule, NCAM
CD56; MSK39; NCAM; NCAM1