|Tested species reactivity||Human|
|Published species reactivity||Human, Not Applicable|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Small cell lung carcinoma.|
|Contains||0.09% sodium azide|
|Storage Conditions||4°C or -20°C if preferred|
|Tested Applications||Dilution *|
|Immunohistochemistry (Frozen) (IHC (F))||1:100-1:200|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100 - 1:200|
|Western Blot (WB)||1:100-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-06801 detects NCAM in human samples.
MA1-06801 has sucessfully been used in Western blotting, immunohistochemistry, and immunocytochemistry procedures.
The MA1-06801 immunogen a membrane preparation of a small cell lung carcinoma.
NCAM, as a member of the immunoglobulin superfamily of adhesion molecules is characterized by several immunoglobulin (Ig)-like domains. The extracellular part of NCAM consists of five of these Ig domains and two fibronectin type III homology regions. NCAM is encoded by a single copy gene composed of 26 exons. However, at least 20-30 distinct isoforms can be generated by alternative splicing and by posttranslational modifications, such as sialylation. During sialylation, polysialic acid (PSA) carbohydrates are attached to the extracellular part of NCAM. Through its extracellular region, NCAM mediates homophilic interactions. In addition, NCAM can also undergo heterophilic interactions by binding extracellular matrix components, such as laminin, or other cell adhesion molecules, such as integrins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Not Applicable||Not Cited||
Variable Expression of Neural Cell Adhesion Molecule Isoforms in Renal Tissue: Possible Role in Incipient Renal Fibrosis.
MA1-06801 was used in immunohistochemistry - paraffin section to learn the possible role of incipient renal fibrosis by variable expression of neural cell adhesion molecule isoforms in renal tissue
|Markovi¿-Lipkovski J,¿ivoti¿ M,Müller CA,Tampe B,¿irovi¿ S,Vje¿tica J,Tomanovi¿ N,Zeisberg M,Müller GA||PloS one (10:null)||2015|
Reevaluation and reclassification of resected lung carcinomas originally diagnosed as squamous cell carcinoma using immunohistochemical analysis.
MA1-06801 was used in immunohistochemistry - paraffin section to determine if immunohistochemical analysis can be used to re-classify lung carcinomas that were originally diagnosed as squamous cell carcinoma
|Kadota K,Nitadori J,Rekhtman N,Jones DR,Adusumilli PS,Travis WD||The American journal of surgical pathology (39:1170)||2015|
Role of cd56 and e-cadherin expression in the differential diagnosis of papillary thyroid carcinoma and suspected follicular-patterned lesions of the thyroid: the prognostic importance of e-cadherin.
MA1-06801 was used in immunohistochemistry - paraffin section to discuss how to distinguish follicular variant of PTC from other follicular-patterned lesions of the thyroid.
|Ceyran AB,¿enol S,¿im¿ek BÇ,Sa¿¿ro¿lu J,Ayd¿n A||International journal of clinical and experimental pathology (8:3670)||2015|
Immunological significance of the accumulation of autophagy components in oral squamous cell carcinoma.
MA1-06801 was used in immunohistochemistry - paraffin section to study the relationship between autophagy and anti-tumor immune responses using immunohistochemistry
|Sakakura K,Takahashi H,Kaira K,Toyoda M,Oyama T,Chikamatsu K||Cancer science (106:1)||2015|
|Not Applicable||Not Cited||
Extraosseous (extramedullary) plasmacytomas: a clinicopathologic and immunophenotypic study of 32 Chinese cases.
MA1-06801 was used in immunohistochemistry - paraffin section to determine the clinicopathologic features and diagnosis of extraosseous plasmacytomas
|Zuo Z,Tang Y,Bi CF,Zhang WY,Zhao S,Wang XQ,Yang QP,Zou LQ,Liu WP||Diagnostic pathology (6:null)||2011|
Pagetoid reticulosis tumor cells with double expression of TCR¿¿ and TCR¿ß: an off-target phenomenon or genuine expression?
MA1-06801 was used in immunohistochemistry to describe the gluteal lesions of a patient with pagetoid reticulosis
|Tomasini D,Niccoli A,Crivelli F||Journal of cutaneous pathology (42:427)||2015|
A Case of Distal Epithelioid Sarcoma of the Thumb Expressing Podoplanin, TLE1 and Ca 125.
MA1-06801 was used in immunohistochemistry to characterize the case of a distal epithelioid sarcoma arising in the thumb of a 14-year-old girl
|Karagkounis G,Argyrakos T,Charkiolakis G,Castana O,Rontogianni D||Case reports in pathology (2013:null)||2013|
|Not Applicable||Not Cited||
Subcutaneous panniculitis-like T-cell lymphoma: a clinical and pathologic study of 14 korean patients.
MA1-06801 was used in immunohistochemistry to study subcutaneous panniculitis-like T-cell lymphomas in Korean patients
|Lee DW,Yang JH,Lee SM,Won CH,Chang S,Lee MW,Choi JH,Moon KC||Annals of dermatology (23:329)||2011|
Primary central nervous system peripheral T-cell lymphoma in a child.
MA1-06801 was used in immunohistochemistry to report on a case of primary central nervous system peripheral T-cell lymphoma in a child
|Gualco G,Wludarski S,Hayashi-Silva L,Medeiros Filho P,Veras G,Bacchi CE||Fetal and pediatric pathology (29:224)||2010|
Atypical carcinoid with prominent mucinous stroma: a hitherto unreported variant of pulmonary neuroendocrine tumor.
MA1-06801 was used in immunohistochemistry to report on a case of atypical carcinoid with prominent mucinous stroma
|Nannini N,Bertolini F,Cavazza A,Casali C,Mengoli MC,Rossi G||Endocrine pathology (21:120)||2010|
Primary plasmacytoma of the cervix in a 21-year-old female patient.
MA1-06801 was used in immunohistochemistry to report on a case of primary plasmacytoma of the cervix
|Schor AP,Moraes MP,Bisson FW,Bisson MA,Luiz OM,Bacchi CE||International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists (29:290)||2010|
EGFR and K-ras mutations along the spectrum of pulmonary epithelial tumors of the lung and elaboration of a combined clinicopathologic and molecular scoring system to predict clinical responsiveness to EGFR inhibitors.
MA1-06801 was used in immunohistochemistry to develop a combined clinicopathologic and molecular scoring system for assessing the tumor responses to EGFR inhibitors
|Sartori G,Cavazza A,Sgambato A,Marchioni A,Barbieri F,Longo L,Bavieri M,Murer B,Meschiari E,Tamberi S,Cadioli A,Luppi F,Migaldi M,Rossi G||American journal of clinical pathology (131:478)||2009|
Composite lymphoma: EBV-positive classic Hodgkin lymphoma and peripheral T-cell lymphoma: a case report.
MA1-06801 was used in immunohistochemistry to report on a case of composite EBV-positive classic Hodgkin lymphoma and peripheral T-cell lymphoma
|Gualco G,Chioato L,Van Den Berg A,Weiss LM,Bacchi CE||Applied immunohistochemistry and molecular morphology : AIMM (17:72)||2009|
TTF-1, cytokeratin 7, 34betaE12, and CD56/NCAM immunostaining in the subclassification of large cell carcinomas of the lung.
MA1-06801 was used in immunohistochemistry to study the use of a number of immunohistochemical markers for the subclassification of large cell carcinomas of the lung
|Rossi G,Marchioni A,Milani M,Scotti R,Foroni M,Cesinaro A,Longo L,Migaldi M,Cavazza A||American journal of clinical pathology (122:884)||2004|
The prognostic role of c-kit protein expression in resected large cell neuroendocrine carcinoma of the lung.
MA1-06801 was used in immunohistochemistry to study the prognostic value of c-kit protein expression in resected large cell neuroendocrine carcinoma
|Casali C,Stefani A,Rossi G,Migaldi M,Bettelli S,Parise A,Morandi U||The Annals of thoracic surgery (77:247)||2004|
Desmoplastic and spindle cell melanomas express protein markers of the neural crest but not of later committed stages of Schwann cell differentiation.
MA1-06801 was used in immunohistochemistry to investigate the expression of unique protein markers in desmoplastic and spindle cell melanomas
|Huttenbach Y,Prieto VG,Reed JA||Journal of cutaneous pathology (29:562)||2002|
CD30(+) extranodal natural killer/T-cell lymphoma mimicking phlegmonous myositis: A case report.
MA1-06801 was used in immunohistochemistry (paraffin) to report on a case of CD30-positive extranodal natural killer/T-cell lymphoma.
|Yang YJ,Li YX,Liu YB,Yang M,Liu K||Oncology letters (7:1419)||2014|
Serous effusion cytology of extranodal natural killer/T-cell lymphoma.
MA1-06801 was used in flow cytometry to characterize extranodal natural killer/T-cell lymphoma, nasal type using patient samples.
|Su XY,Huang J,Jiang Y,Tang Y,Li GD,Liu WP||Cytopathology : official journal of the British Society for Clinical Cytology (23:96)||2012|
Goblet cell carcinoid of the appendix: a clinicopathological and immunohistochemical study of 26 cases from southwest china.
MA1-06801 was used in immunohistochemistry - paraffin section to report the clinicopathological and immunohistochemical features of goblet cell carcinoid
|International journal of surgical pathology (18:488)||2010|