|Tested species reactivity||Human, Pig|
|Host / Isotype||Mouse / IgM|
|Immunogen||Human peripheral blood lymphocytes.|
|Storage buffer||HEPES buffered saline, pH 7.0|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||2-8 ug/ml|
|Functional Assay (FN)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
CD59 (Protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). It is thus the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 associates with C5b-8 complex and thereby counteracts appropriate formation of cytolytic pore within the plasma membrane. CD59 is also an low-affinity ligand of human CD2 and causes T cell costimulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.