|Tested species reactivity||Human|
|Published species reactivity||Human, Not Applicable|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Thymocytes and T lymphocytes.|
|Storage buffer||PBS with 0.2% BSA|
|Contains||15mM sodium azide|
|Storage Conditions||4° C, store in dark, DO NOT FREEZE!|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||20ul/100ul whole blood|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
CD59 (Protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). It is thus the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 associates with C5b-8 complex and thereby counteracts appropriate formation of cytolytic pore within the plasma membrane. CD59 is also an low-affinity ligand of human CD2 and causes T cell costimulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Rare event counting of CD59- red cells in human blood: A 47-month experience using PNH consensus guidelines for WBC and RBC testing in a reference lab.
MA1-19639 was used in flow cytometry to discuss the features of paroxysmal nocturnal hemoglobinuria.
|Liew M,Farley M,Andreasen J,Parker CJ,Wittwer CT||Cytometry. Part B, Clinical cytometry (88:261)||2015|
|Not Applicable||Not Cited||
Thrice-weekly low-dose rituximab decreases CD20 loss via shaving and promotes enhanced targeting in chronic lymphocytic leukemia.
MA1-19639 was used in flow cytometry to examine loss of CD20 in chronic lymphocytic leukemia
|Williams ME,Densmore JJ,Pawluczkowycz AW,Beum PV,Kennedy AD,Lindorfer MA,Hamil SH,Eggleton JC,Taylor RP||Journal of immunology (Baltimore, Md. : 1950) (177:7435)||2006|
Increased expression of phosphatidylinositol-specific phospholipase C resistant prion proteins on the surface of activated platelets.
MA1-19639 was used in flow cytometry to investigate the cellular processing of PrP (C) using platelets.
|Holada K,Mondoro TH,Muller J,Vostal JG||British journal of haematology (103:276)||1998|