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      View (18) other CD63 antibodies

      Invitrogen

      CD63 Monoclonal Antibody (Ts63)

      Published Figures 3 Published Figures
      References Icon 4 References
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      Catalog # 10628D

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      Product Details

      TESTED APPLICATIONS DILUTION
      Western Blot (WB) 2 µg/mL
      PUBLISHED APPLICATIONS
      Western Blot (WB) See 4 publications below
      Species reactivity Human
      Published species Human, Mouse
      Host / Isotype Mouse / IgG1
      Class Monoclonal
      Type Antibody
      Clone Ts63
      Immunogen Jurkat and HeLa (human cell lines)
      Conjugate Unconjugated
      Form Liquid
      Concentration 0.5 mg/ml
      Purification purified
      Storage buffer PBS, pH 7.4
      Contains 0.09% sodium azide
      Storage conditions 4° C
      RRID AB_2532983

      Product Specific Information

      Tested in western blotting under non-reducing conditions.

      Background/Target Information

      CD63 (LAMP-3, lysosome-associated membrane protein-3), a glycoprotein of tetraspanin family, is present in late endosomes, lysosomes and secretory vesicles of various cell types. It is also present in the plasma membrane, usually following cell activation. Hence, it has become an widely used basophil activation marker. In mast cells, however, CD63 exposition does not need their activation. CD63 interacts with integrins and affects phagocytosis and cell migration, it is also involved in H/K-ATPase trafficking regulation of ROMK1 channels. CD63 also serves as a T-cell costimulation molecule. Expression of CD63 can be used for predicting the prognosis in earlier stages of carcinomas.

      For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

      References (4)

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      Bioinformatics

      Protein Aliases: CD63; CD63 antigen; CD63 antigen (melanoma 1 antigen); Granulophysin; LAMP-3; Lysosomal-associated membrane protein 3; lysosome-associated membrane glycoprotein 3; ME491; Melanoma-associated antigen ME491; melanoma-associated antigen MLA1; MLA1; Ocular melanoma-associated antigen; OMA81H; Tetraspanin-30; Tspan-30; TSPAN30

      Gene Aliases: CD63; LAMP-3; ME491; MLA1; OMA81H; TSPAN30

      UniProt ID: (Human) P08962

      Entrez Gene ID: (Human) 967

      Molecular Function: cell adhesion molecule membrane-bound signaling molecule receptor signaling molecule

      Suggested Secondary Antibodies

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      Material safety data sheets (MSDS)

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