|Tested species reactivity||Mouse|
|Published species reactivity||Mouse, Not Applicable|
|Host / Isotype||Armenian hamster / IgG|
|Immunogen||Murine dendritic epidermal T cell line Y245.|
|Storage buffer||proprietary buffer|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
CD69 is a 55-70 kD glycoprotein that under reducing conditions dissociates in 3 components (gp 26,28,34), differentially glycosylated forms of a 21kD protein. CD69 is an early activation antigen also called Activation Inducer Molecule (AIM) that is very early, before antigens such as CD25 and CD71 are expressed strongly on T-cells after activation. CD69 is also expressed by activated B-lymphocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
An ISCOM vaccine combined with a TLR9 agonist breaks immune evasion mediated by regulatory T cells in an orthotopic model of pancreatic carcinoma.
A16323 was used in flow cytometry to assess the efficacy of an immune stimulatory complex-based vaccine in a murine pancreatic carcinoma model
|Jacobs C,Duewell P,Heckelsmiller K,Wei J,Bauernfeind F,Ellermeier J,Kisser U,Bauer CA,Dauer M,Eigler A,Maraskovsky E,Endres S,Schnurr M||International journal of cancer (128:897)||2011|
Polyinosinic-polycytidylic acid treatment of Friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced disease.
A16323 was used in flow cytometry to use the Friend retrovirus mouse model to elucidate the mode of action of poly(I:C) in antiretroviral immunotherapy
|Gibbert K,Dietze KK,Zelinskyy G,Lang KS,Barchet W,Kirschning CJ,Dittmer U||Journal of immunology (Baltimore, Md. : 1950) (185:6179)||2010|
Involvement of p38 mitogen-activated protein kinase in different stages of thymocyte development.
A16323 was used in flow cytometry to suggest that p38 is involved in positive selection of T cells.
|Hsu SC,Wu CC,Han J,Lai MZ||Blood (101:970)||2003|
Increased p300 expression inhibits glucocorticoid receptor-T-cell receptor antagonism but does not affect thymocyte positive selection.
A16323 was used in flow cytometry to test if T-cell-specific expression of p300 alters GR-TCR cross talk between thymocytes.
|Yu CT,Feng MH,Shih HM,Lai MZ||Molecular and cellular biology (22:4556)||2002|
|Not Applicable||Not Cited||
General strategy for decoration of enveloped viruses with functionally active lipid-modified cytokines.
A16323 was used in flow cytometry to develop a system for the decoration of enveloped viruses with functionally active cytokines
|Kueng HJ,Leb VM,Haiderer D,Raposo G,Thery C,Derdak SV,Schmetterer KG,Neunkirchner A,Sillaber C,Seed B,Pickl WF||Journal of virology (81:8666)||2007|
|Not Applicable||Not Cited||
Altered function in CD8+ T cells following paramyxovirus infection of the respiratory tract.
A16323 was used in flow cytometry to use infection of the respiratory tract with paramyxovirus simian virus 5 to study lung CD8+ T cell responses
|Gray PM,Arimilli S,Palmer EM,Parks GD,Alexander-Miller MA||Journal of virology (79:3339)||2005|