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CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation.
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Protein Aliases: B-cell differentiation antigen CD72; CD72; Ly-32; Lyb-2; Lymphocyte antigen 32; RP11-331F9.9
Gene Aliases: Cd72; CD72c; Ly-19; Ly-32; Ly-m19; Ly32; Lyb-2
UniProt ID: (Mouse) P21855
Entrez Gene ID: (Mouse) 12517
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