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Product Details
65157-1-IG
| Applications | Tested Dilution | Publications |
|---|---|---|
Flow Cytometry (Flow) |
Assay-dependent | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Mouse / IgG2b |
Class |
Monoclonal |
Type |
Antibody |
Clone |
3F3 |
Immunogen |
Normal human lymphocytes from a lymph node |
Conjugate |
Unconjugated
|
Form |
Liquid |
Concentration |
1 mg/mL |
Purification |
selective precipitation |
Storage buffer |
PBS |
Contains |
0.1% sodium azide |
Storage conditions |
2-8°C |
Target Information
CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B-cell differentiation antigen CD72; CD72; CD72 antigen; Lyb-2; RP11-331F9.9
Gene Aliases: CD72; CD72b; LYB2
UniProt ID: (Human) P21854
Entrez Gene ID: (Human) 971
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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