MA5-11636 targets CD79a in WB, FACS and IHC (P) applications and shows reactivity with Human and Mouse samples. This antibody is not suitable for mouse BAF-3 cell lysates in Western blot analysis. This antibody also detects some non-specific bands on Ramos cell lysates.
The MA5-11636 immunogen is recombinant protein containing part of the extracellular portion of the CD79a glycoprotein.
CD79a is a disulphide-linked heterodimer that includes B29 (CD79b) polypeptide. CD79a is a B lymphocyte antigen receptor with an antigen-specific surface component Ig (immunoglobulin) that associates with Ig-alpha and Ig-beta, necessary elements for the expression and function of the B-cell antigen receptor. CD79a first appears at pre-B cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B cell type, in B cell lines, B cell lymphomas, and in some myelomas. It is not present in myeloid or T cell lines. Diseases associated with CD79a include Agammaglobulinemia 3 and Agammaglobulinemia, Non-Bruton type.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: B-cell antigen receptor complex-associated protein alpha chain; CD79a; CD79a antigen (immunoglobulin-associated alpha); CD79a antigen immunoglobulin-associated alpha; CD79a molecule, immunoglobulin-associated alpha; Ig alpha; Ig-alpha; IGA; immunoglobulin-associated alpha; MB-1; MB-1 membrane glycoprotein; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated protein
Gene Aliases: CD79A; Ig-alpha; IGA; Igalpha; Ly-54; Ly54; MB-1; MB1