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|Tested species reactivity||Mouse|
|Host / Isotype||Armenian hamster / IgG2|
|Immunogen||Purified CD79a/b (alpha/beta) dimers from WEHI231 cells|
|Contains||15mM sodium azide|
|Storage Conditions||4° C, store in dark, DO NOT FREEZE!|
|Tested Applications||Dilution *|
|Flow Cytometry (FACS)||2 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody does not react with human samples.
CD79b (Ig beta, B29) forms disulfide-linked heterodimer with CD79a (Ig alpha, MB1). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
B-cell antigen receptor complex-associated protein beta chain; B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein; immunoglobulin-associated beta
B29; Ig-beta; Igb; Igbeta