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|Tested species reactivity||Human|
|Published species reactivity||Human, Mouse, Rhesus monkey|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||Recognizes the CD8 antigen|
|Conjugate||Alexa Fluor® 405|
|Contains||0.1% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
CD8 molecule is composed of two chains termed alpha and beta. CD8 is found on a T cell subset of normal cytotoxic / suppressor cells which make up approximately 20 to 35 % of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer cells, 80% of thymocytes, on a subpopulation of 30% of peripheral blood null cells and 15 to 30% of bone marrow cells. CD38 (T10) is a single chain 46 kDa type II integral glycoprotein with a short N terminal cytoplasmic tail. CD38 is highly expressed on thymocytes. It is also expressed by early cells of B and T lineages, NK cells, plasma cells, monocytes and macrophages and may be detected on cells from multiple myeloma, ALL (B and T) and some AML. In normal lymph nodes and tonsils the antigen is detected mainly on B cells in germinal centers and in plasma cells. The extracellular domain of the molecule shares a high homology sequence with Aplysia ADP ribosyl cyclase. CD38 functions as a multicatalytic ectoenzyme serving as ADP ribosyl cyclase, ADPR hydrolase and possibly NAD+ glycohydrolase, or as a surface receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Comparative analysis of SIV-specific cellular immune responses induced by different vaccine platforms in rhesus macaques.
MHCD0826 was used in immunocytochemistry to compare five SIV vaccine platforms
|Valentin A,McKinnon K,Li J,Rosati M,Kulkarni V,Pilkington GR,Bear J,Alicea C,Vargas-Inchaustegui DA,Jean Patterson L,Pegu P,Liyanage NP,Gordon SN,Vaccari M,Wang Y,Hogg AE,Frey B,Sui Y,Reed SG,Sardesai NY,Berzofsky JA,Franchini G,Robert-Guroff M,Felber BK,Pavlakis GN||Clinical immunology (Orlando, Fla.) (155:91)||2014|
Syncytin proteins incorporated in placenta exosomes are important for cell uptake and show variation in abundance in serum exosomes from patients with preeclampsia.
MHCD0826 was used in flow cytometry to study the role of human endogenous retrovirus (HERV) envelope proteins in the uptake of exosomes
|Vargas A,Zhou S,Éthier-Chiasson M,Flipo D,Lafond J,Gilbert C,Barbeau B||FASEB journal : official publication of the Federation of American Societies for Experimental Biology (28:3703)||2014|
|Rhesus monkey||Not Cited||
Altered response hierarchy and increased T-cell breadth upon HIV-1 conserved element DNA vaccination in macaques.
MHCD0826 was used in flow cytometry to compare vaccination with highly conserved gag elements verses full-length gag DNA.
|Kulkarni V,Valentin A,Rosati M,Alicea C,Singh AK,Jalah R,Broderick KE,Sardesai NY,Le Gall S,Mothe B,Brander C,Rolland M,Mullins JI,Pavlakis GN,Felber BK||PloS one (9:null)||2014|
|Rhesus monkey||Not Cited||
IL-12 DNA as molecular vaccine adjuvant increases the cytotoxic T cell responses and breadth of humoral immune responses in SIV DNA vaccinated macaques.
MHCD0826 was used in flow cytometry to study the use of an IL-2 adjuvant when vaccinating rhesus macaques.
|Jalah R,Patel V,Kulkarni V,Rosati M,Alicea C,Ganneru B,von Gegerfelt A,Huang W,Guan Y,Broderick KE,Sardesai NY,LaBranche C,Montefiori DC,Pavlakis GN,Felber BK||Human vaccines & immunotherapeutics (8:1620)||2012|
CD8; CD8 antigen, alpha polypeptide (p32); CD8 antigen, beta polypeptide 1 (p37); CD8a; CD8alpha; CD8b; CD8beta; Leu-2; Leu2 T-lymphocyte antigen; MAL; OKT8 T-cell antigen; T cell co-receptor; T lymphocyte surface glycoprotein beta chain; T-cell antigen Leu2; T-lymphocyte differentiation antigen T8/Leu-2; T8 T-cell antigen
CD8; CD8A; CD8B; CD8B1; LEU2; LY3; LYT3; MAL; p32; P37