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|Tested species reactivity||Human|
|Published species reactivity||Rat, Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to the C-terminus of alpha chain of the human CD8 molecule|
|Storage buffer||tissue culture supernatant diluted in TBS, pH 7.5, with 1% BSA|
|Contains||<0.1% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 30 min at room temperature. A suggested positive control is tonsil tissue.
CD8 molecule consists of two chains, termed a and ß chain, which aree expressed as a disulphide-linked a/ß heterdimer or as an a/a homodimer on
T cell subset, thymocytes and NK cells. The majority of CD8+ T cells express CD8 as a/ß heterdimer. CD8 functions as a coreceptor in concert
with TCR for binding the MHC class I/peptide complex. The HIV-2 envelope glycoprotein binds CD8 a chain (but not ß chain).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CUX1 modulates polarization of tumor-associated macrophages by antagonizing NF-κB signaling.
MA1-39566 was used in immunocytochemistry to study the role of NFkB in the mechanism by which CUX1 regulates tumor-associated macrophage functionality
|Kühnemuth B,Mühlberg L,Schipper M,Griesmann H,Neesse A,Milosevic N,Wissniowski T,Buchholz M,Gress TM,Michl P||Oncogene (34:177)||2015|
High infiltration of tumor-associated macrophages in triple-negative breast cancer is associated with a higher risk of distant metastasis.
MA1-39566 was used in immunohistochemistry - paraffin section to study the prognostic significance of the infiltration of tumor associate macrophages in patients with triple negative breast cancer
|Yuan ZY,Luo RZ,Peng RJ,Wang SS,Xue C||OncoTargets and therapy (7:1475)||2014|
Low intraprostatic DHT promotes the infiltration of CD8+ T cells in BPH tissues via modulation of CCL5 secretion.
MA1-39566 was used in immunohistochemistry to study the role of CCL5 secretion in the mechanism by which CD8(+) T-cell infiltration of benign prostatic hyperplasia tissue is enhanced by low dihydroxytestosterone levels
|Fan Y,Hu S,Liu J,Xiao F,Li X,Yu W,Cui Y,Sun M,Lv T,He Q,Jin J||Mediators of inflammation (2014:null)||2014|
Prognostic implications of tumor-infiltrating FoxP3+ regulatory T cells and CD8+ cytotoxic T cells in microsatellite-unstable gastric cancers.
MA1-39566 was used in immunohistochemistry to study the prognostic value of FoxP3-positive regulatory T-cells and CD8-positive cytotoxic T-cells in gastric cancers with high microsatellite instability
|Kim KJ,Lee KS,Cho HJ,Kim YH,Yang HK,Kim WH,Kang GH||Human pathology (45:285)||2014|
T cell-activation in neuromyelitis optica lesions plays a role in their formation.
MA1-39566 was used in immunohistochemistry to study the role of T-cell activation in the formation of neuromyelitis optica lesions
|Pohl M,Kawakami N,Kitic M,Bauer J,Martins R,Fischer MT,Machado-Santos J,Mader S,Ellwart JW,Misu T,Fujihara K,Wekerle H,Reindl M,Lassmann H,Bradl M||Acta neuropathologica communications (1:null)||2014|
Expression of CD8 is associated with non-common type morphology and outcome in pediatric anaplastic lymphoma kinase-positive anaplastic large cell lymphoma.
MA1-39566 was used in immunohistochemistry to study the prognostic value of CD8 expression in pediatric anaplastic lymphoma kinase-positive anaplastic large cell lymphoma and its association with non-common type morphology
|Abramov D,Oschlies I,Zimmermann M,Konovalov D,Damm-Welk C,Wössmann W,Klapper W||Haematologica (98:1547)||2013|
Tumor-infiltrating lymphocytes, tumor characteristics, and recurrence in patients with early breast cancer.
MA1-39566 was used in immunohistochemistry to study the relationships between tumor-infiltrating lymphocytes, breast cancer characteristics and tumor recurrence
|Kim ST,Jeong H,Woo OH,Seo JH,Kim A,Lee ES,Shin SW,Kim YH,Kim JS,Park KH||American journal of clinical oncology (36:224)||2013|
Anaplastic large cell lymphoma with paraneoplastic leukocytosis: a clinicopathological analysis of five cases.
MA1-39566 was used in immunohistochemistry to report on five cases of anaplastic large cell lymphoma with paraneoplastic leukocytosis
|Chang IW,Chen HK,Ma MC,Huang WT||APMIS : acta pathologica, microbiologica, et immunologica Scandinavica (119:794)||2011|
Study of cellular immune response against Hepatitis E virus (HEV).
MA1-39566 was used in immunohistochemistry to investigate the immunopathology of hepatitis E virus infection
|Prabhu SB,Gupta P,Durgapal H,Rath S,Gupta SD,Acharya SK,Panda SK||Journal of viral hepatitis (18:587)||2011|
CD8⁺ T cells with an intraepithelial phenotype upregulate cytotoxic function upon influenza infection in human lung.
MA1-39566 was used in immunohistochemistry to identify the role of CD103+CD8+ T cells in protection against respiratory viruses
|Piet B,de Bree GJ,Smids-Dierdorp BS,van der Loos CM,Remmerswaal EB,von der Thüsen JH,van Haarst JM,Eerenberg JP,ten Brinke A,van der Bij W,Timens W,van Lier RA,Jonkers RE||The Journal of clinical investigation (121:2254)||2011|
Spatial differences in the presence of FOXP3+ and GranzymeB+ T cells between the intra- and extravascular compartments in renal allograft vasculopathy.
MA1-39566 was used in immunohistochemistry to investigate the differences of T cell subtypes between the intra- and extravascular compartments in renal allograft vasculopathy
|de Boer OJ,Teeling P,Jansen M,Ploegmakers H,van der Loos CM,Kummer JA,Florquin S,van der Wal AC||PloS one (6:null)||2011|
Hepatitis C virus induces the expression of CCL17 and CCL22 chemokines that attract regulatory T cells to the site of infection.
MA1-39566 was used in immunohistochemistry to study the role of CCL17 and CCL22 in Foxp3+ T regulatory cell accumulation at the site of HCV infection
|Riezu-Boj JI,Larrea E,Aldabe R,Guembe L,Casares N,Galeano E,Echeverria I,Sarobe P,Herrero I,Sangro B,Prieto J,Lasarte JJ||Journal of hepatology (54:422)||2011|
Antagonism of TIM-1 blocks the development of disease in a humanized mouse model of allergic asthma.
MA1-39566 was used in immunohistochemistry to investigate the role of the TIM-1 pathway in T cell activation and allergic asthma
|Sonar SS,Hsu YM,Conrad ML,Majeau GR,Kilic A,Garber E,Gao Y,Nwankwo C,Willer G,Dudda JC,Kim H,Bailly V,Pagenstecher A,Rennert PD,Renz H||The Journal of clinical investigation (120:2767)||2010|
Primary central nervous system peripheral T-cell lymphoma in a child.
MA1-39566 was used in immunohistochemistry to report on a case of primary central nervous system peripheral T-cell lymphoma in a child
|Gualco G,Wludarski S,Hayashi-Silva L,Medeiros Filho P,Veras G,Bacchi CE||Fetal and pediatric pathology (29:224)||2010|
Increased T-bet+ cytotoxic effectors and type I interferon-mediated processes in chronic graft-versus-host disease of the oral mucosa.
MA1-39566 was used in immunohistochemistry to investigate the pathogenesis of chronic graft-versus-host disease
|Imanguli MM,Swaim WD,League SC,Gress RE,Pavletic SZ,Hakim FT||Blood (113:3620)||2009|
GMP-17-positive T-lymphocytes in renal tubules predict progression in early stages of IgA nephropathy.
MA1-39566 was used in immunohistochemistry to investigate the predictive value of GMP-17-positive T-lymphocytes in IgA nephropathy
|van Es LA,de Heer E,Vleming LJ,van der Wal A,Mallat M,Bajema I,Bruijn JA,de Fijter JW||Kidney international (73:1426)||2008|
Selective expansion of influenza A virus-specific T cells in symptomatic human carotid artery atherosclerotic plaques.
MA1-39566 was used in immunohistochemistry to study the role of influenza A virus infection in atherothrombotic disease
|Keller TT,van der Meer JJ,Teeling P,van der Sluijs K,Idu MM,Rimmelzwaan GF,Levi M,van der Wal AC,de Boer OJ||Stroke; a journal of cerebral circulation (39:174)||2008|
Effect of melatonin and zinc on the immune response in experimental Toxoplasma retinochoroiditis.
MA1-39566 was used in immunohistochemistry to investigate the impact of melatonin and zinc on immune and inflammatory responses to Toxoplasma retinochoroiditis in a rat model
|Avunduk AM,Avunduk MC,Baltaci AK,Moğulkoç R||Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fu¿r Augenheilkunde (221:421)||2007|
Intrahepatic virus-specific IL-10-producing CD8 T cells prevent liver damage during chronic hepatitis C virus infection.
MA1-39566 was used in immunohistochemistry to investigate the role of CD8 T cells in the liver damage during chronic hepatitis C virus infection
|Abel M,Sène D,Pol S,Bourlière M,Poynard T,Charlotte F,Cacoub P,Caillat-Zucman S||Hepatology (Baltimore, Md.) (44:1607)||2006|
CD8; CD8 antigen, alpha polypeptide (p32); CD8 antigen, beta polypeptide 1 (p37); CD8a; CD8alpha; CD8b; CD8beta; Leu-2; Leu2 T-lymphocyte antigen; MAL; OKT8 T-cell antigen; T cell co-receptor; T lymphocyte surface glycoprotein beta chain; T-cell antigen Leu2; T-lymphocyte differentiation antigen T8/Leu-2; T8 T-cell antigen
CD8; CD8A; CD8B; CD8B1; LEU2; LY3; LYT3; MAL; p32; P37