|Tested species reactivity||Mouse|
|Published species reactivity||Mouse, Not Applicable|
|Host / Isotype||Rat / IgG2b|
|Clone||YTS 169AG 101HL|
|Immunogen||Mouse Ly-2 thymocytes.|
|Contains||0.02% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1 ug/1 million cells|
|Immunohistochemistry (Frozen) (IHC (F))||Assay Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-70041 detects CD8a in mouse samples.
MA1-70041 has been successfully used in flow cytometry and immunohistochemistry (PFA-fixed paraffin and frozen) procedures. PFA-fixed paraffin-embedded tissue sections require antigen retrieval prior to immunostaining.
The MA1-70041 immunogen is mouse Ly-2 thymocytes.
Store at 4°C for short term. For extended storage aliquot and store at -20°C. Avoid Freeze/Thaw Cycles.
MA1-70041 reacts with a protein of approximately 30 kDa found on mouse thymocytes and mouse cytotoxic/suppressor T cells. It does not bind to mouse helper/inducer T cells. It binds to T lymphocytes from all mouse strains regardless of phenotypic expressin (i.e. reacts with T lymphocytes from mouse strains expresssing the Ly2.1 or Ly2.2 phenotype). It can be used to investigate the role of T cells in models for infectious disease, autoimmunity transplantation tolerance and fundamental aspects of immunology. It can also be useful to identify/eliminate cytotoxic or suppressor T lyphocytes in vivo or in vitro.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Pancreatic Tissue Transplanted in TheraCyte Encapsulation Devices Is Protected and Prevents Hyperglycemia in a Mouse Model of Immune-Mediated Diabetes.
MA1-70041 was used in immunohistochemistry - paraffin section to study transplantation of pancreatic tissue in TheraCyte encapsulation devices that is protected and prevents hyperglycemia in an mouse model of immune-mediated diabetes
|Boettler T,Schneider D,Cheng Y,Kadoya K,Brandon EP,Martinson L,von Herrath M||Cell transplantation (25:609)||2016|
Consequences of the combined loss of BOK and BAK or BOK and BAX.
MA1-70041 was used in flow cytometry to determine if Bok and Bax have any functional redundancy controlling apoptosis using knock out mice.
|Ke F,Bouillet P,Kaufmann T,Strasser A,Kerr J,Voss AK||Cell death and disease (4:null)||2013|
Adenosine A2A receptor: a target for regulating renal interstitial fibrosis in obstructive nephropathy.
MA1-70041 was used in immunohistochemistry to study the ability of adenosine A2A receptor activation to inhibit epithelial-mesenchymal transition and the development of renal interstitial fibrosis in a murine model
|Xiao H,Shen HY,Liu W,Xiong RP,Li P,Meng G,Yang N,Chen X,Si LY,Zhou YG||PloS one (8:null)||2013|