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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1/IgG2a|
|Immunogen||human peripheral blood T lymphocytes|
|Conjugate||FITC , PE|
|Storage buffer||PBS with 0.2% carrier protein|
|Contains||0.08% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody is a monoclonal mixture of FITC-conjugated CD8 (clone 17D8, isotype IgG1) and PE-conjugated CD11a (clone OFYS, isotype IgG2a).
CD8 molecule is composed of two chains termed alpha and beta. CD8 is found on a T cell subset of normal cytotoxic / suppressor cells which make up approximately 20 to 35 % of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer cells, 80% of thymocytes, on a subpopulation of 30% of peripheral blood null cells and 15 to 30% of bone marrow cells. CD11a is a glycoprotein with a molecular weight of 26 kDa expressed in combination with the CD18 beta chain. The complex is a member of the beta2 integrin family. These molecules function in cell adhesion and specifically bind to CD54, ICAM-2, ICAM-3. CD11a is expressed on lymphocytes, granulocytes, monocytes, and macrophages and is upregulated on activated T-cells. Anti-CD11a from I21/7 reacts with 97% of thymocytes, 95% of blood lymphocytes, 70% of bone marrow cells of all mouse strains tested.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
antigen CD11A (p180); antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide; antigen CD11A p180; CD11 antigen-like family member A; CD11a; CD8; CD8 antigen, alpha polypeptide (p32); CD8 antigen, beta polypeptide 1 (p37); CD8a; CD8alpha; CD8b; CD8beta; integrin alpha L; Integrin alpha-L; integrin gene promoter; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide); ITGAL; Leu-2; Leu2 T-lymphocyte antigen; Leukocyte adhesion glycoprotein LFA-1 alpha chain; Leukocyte function-associated molecule 1 alpha chain; LFA-1 alpha; LFA-1A; lymphocyte function-associated antigen 1; lymphocyte function-associated antigen 1 alpha polypeptide; lymphocyte function-associated antigen 1, alpha polypeptide; MAL; OKT8 T-cell antigen; T cell co-receptor; T lymphocyte surface glycoprotein beta chain; T-cell antigen Leu2; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 beta chain; T-lymphocyte differentiation antigen T8/Leu-2; T8 T-cell antigen
CD11A; CD8; CD8A; CD8B; CD8B1; ITGAL; LEU2; LFA-1; LFA1A; LY3; LYT3; MAL; p32; P37