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CD8 molecule is composed of two chains termed alpha and beta. CD8 is found on a T cell subset of normal cytotoxic / suppressor cells which make up approximately 20 to 35 % of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer cells, 80% of thymocytes, on a subpopulation of 30% of peripheral blood null cells and 15 to 30% of bone marrow cells. CD16 is a 50-65kD cell surface molecule which exists in two forms - a transmembranous form expressed by NK cells and some T cells and a phosphatidylinositol linked form expressed by granulocytes. CD16 is a low affinity receptor for IgG (FcR III), and is an important receptor mediating ADCC by NK cells.
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Protein Aliases: CD16/CD8; CD16a; CD16a antigen; CD16b; CD8; CD8 antigen 32 kDa chain; CD8 antigen 37 kDa chain; CD8 antigen alpha-chain; CD8 antigen beta-chain; CD8 antigen, alpha chain; CD8 antigen, alpha polypeptide (p32); CD8 antigen, alpha-chain; CD8 antigen, beta chain; CD8 antigen, beta polypeptide 1 (p37); CD8 antigen, beta-chain; CD8a; CD8b; Fc fragment of IgG intermediate affinity IV receptor; Fc fragment of IgG low affinity IIIa receptor; Fc fragment of IgG, low affinity III, receptor for (CD16); Fc fragment of IgG, low affinity IIIa, receptor; Fc fragment of IgG, low affinity IIIa, receptor (CD16a); Fc fragment of IgG, low affinity IIIa, receptor for (CD16); Fc fragment of IgG, low affinity IIIb, receptor (CD16b); Fc gamma receptor III-A; Fc gamma receptor IIIa; Fc gamma receptor IIIb; Fc-gamma receptor III-2 (CD 16); Fc-gamma receptor IIIb (CD 16); Fc-gamma receptor IIIb (CD16); Fc-gamma RIII; Fc-gamma RIII-alpha; Fc-gamma RIII-beta; Fc-gamma RIIIa; fc-gamma RIIIb; FcgammaRIIIA; FcR-10; IgG Fc receptor III-1; IgG Fc receptor III-2; immunoglobulin G Fc receptor III; Leu2 T-lymphocyte antigen; Low affinity immunoglobulin gamma Fc region receptor III-A; Low affinity immunoglobulin gamma Fc region receptor III-B; Lyt-2.1 lymphocyte differentiation antigen (AA at 100); neutrophil-specific antigen NA; OKT8 T-cell antigen; OX-8 membrane antigen; T cell co-receptor; T lymphocyte surface glycoprotein beta chain; T-cell antigen Leu2; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 beta chain; T-cell surface glycoprotein Lyt-2; T-lymphocyte differentiation antigen T8/Leu-2; T8 T-cell antigen; transmembrane receptor FcgammaRIII-X
Gene Aliases: BB154331; CD16; CD16A; CD16B; CD8; CD8A; CD8B; CD8B1; FCG3; FCGR3; FCGR3A; FCGR3B; Fcgr4; FCGRIII; FCR-10; FCRIII; FCRIIIA; FCRIIIb; IGFR3; IMD20; LEU2; Ly-2; Ly-35; Ly-B; LY3; Lyt-2; Lyt2; LYT3; MAL; p32; P37
UniProt ID: (Human) P01732, (Human) P10966, (Mouse) P01731, (Rat) P07725, (Rat) P05541, (Human) P08637, (Human) O75015
Entrez Gene ID: (Human) 925, (Human) 926, (Mouse) 12525, (Rat) 24930, (Rat) 24931, (Human) 2214, (Human) 2215, (Rat) 304966
Molecular Function:
cytokine receptor
defense/immunity protein
immunoglobulin receptor superfamily
receptor
cell adhesion molecule
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