|Flow Cytometry (Flow)||Assay Dependent|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||human peripheral blood monocytes from a rheumatoid arthritis patient and human peripheral blood T lymphocytes|
|Conjugate||FITC , PE|
|Excitation/Emission Profile||View spectra|
|Storage buffer||PBS with 0.2% carrier protein|
|Contains||0.08% sodium azide|
|Storage conditions||4° C, do not freeze|
This antibody is a monoclonal mixture of FITC-conjugated CD8 (clone 17D8, isotype IgG1) and PE-conjugated CD45RA (clone BHKG-2, isotype IgG1).
CD8 molecule is composed of two chains termed alpha and beta. CD8 is found on a T cell subset of normal cytotoxic / suppressor cells which make up approximately 20 to 35 % of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer cells, 80% of thymocytes, on a subpopulation of 30% of peripheral blood null cells and 15 to 30% of bone marrow cells. CD45 Leukocyte Common Antigen (LCA) belongs to the family of at least four isoforms of membrane glycoproteins (220, 205, 190, 180 kDa) expressed on hematopoietic cell lines but absent on non-hematopoietic cell lines, normal and malignant, non-hematopoietic tissues. The intracellular portion of these molecules have protein phosphatase activity and are involved in regulation of transmembrane signals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: B220; c polypeptide; CD45; CD45 antigen; CD45R; CD8; CD8 antigen, alpha polypeptide (p32); CD8 antigen, beta polypeptide 1 (p37); CD8a; CD8alpha; CD8b; CD8beta; GP180; L-CA; LCA; Leu-2; Leu2 T-lymphocyte antigen; Leukocyte common antigen; LY5; MAL; OKT8 T-cell antigen; protein tyrosine phosphatase; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; PTPRC; receptor type; Receptor-type tyrosine-protein phosphatase C; T cell co-receptor; T lymphocyte surface glycoprotein beta chain; T-cell antigen Leu2; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 beta chain; T-lymphocyte differentiation antigen T8/Leu-2; T200; T200 glycoprotein; T200 leukocyte common antigen; T8 T-cell antigen
Gene Aliases: B220; CD45; CD45R; CD8; CD8A; CD8B; CD8B1; GP180; L-CA; LCA; LEU2; LY3; LY5; LYT3; MAL; p32; P37; PTPRC; T200
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