|Tested species reactivity||Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Rat / IgG2a|
|Immunogen||Mouse spleen cells|
|Storage buffer||PBS, pH 7.4|
|Contains||15mM sodium azide|
|Storage Conditions||4° C, store in dark, DO NOT FREEZE!|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||2 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Miscellaneous PubMed (MISC)||See 3 publications below|
The CD8a (CD8 alpha) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells, intraepithelial lymphocytes, NK cells, macrophages and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
The source of early IFN-gamma that plays a role in Th1 priming.
MA1-10303 was used in flow cytometry to identify the source of the early IFN-gamma after injection with anti-CD3.
|Das G,Sheridan S,Janeway CA||Journal of immunology (Baltimore, Md. : 1950) (167:2004)||2001|
Oral administration of the bacterial superantigen staphylococcal enterotoxin B induces activation and cytokine production by T cells in murine gut-associated lymphoid tissue.
MA1-10303 was used in flow cytometry to compare gut and peripheral T cell responses after staphylococcal enterotoxin treatment.
|Spiekermann GM,Nagler-Anderson C||Journal of immunology (Baltimore, Md. : 1950) (161:5825)||1998|
B7 blockade prevents activation-induced cell death of thymocytes.
MA1-10303 was used in flow cytometry to elucidate the role of B7 in thymic selection.
|Samoilova EB,Horton JL,Bassiri H,Zhang H,Linsley PS,Carding SR,Chen Y||International immunology (9:1663)||1997|