|Tested species reactivity||Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Rat / IgG2a, kappa|
|Storage buffer||PBS, pH 7.2, with 0.1% gelatin|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Miscellaneous PubMed (MISC)||See 3 publications below|
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a corepressor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains, or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
The source of early IFN-gamma that plays a role in Th1 priming.
A18649 was used in flow cytometry to identify the source of the early IFN-gamma after injection with anti-CD3.
|Das G,Sheridan S,Janeway CA||Journal of immunology (Baltimore, Md. : 1950) (167:2004)||2001|
Oral administration of the bacterial superantigen staphylococcal enterotoxin B induces activation and cytokine production by T cells in murine gut-associated lymphoid tissue.
A18649 was used in flow cytometry to compare gut and peripheral T cell responses after staphylococcal enterotoxin treatment.
|Spiekermann GM,Nagler-Anderson C||Journal of immunology (Baltimore, Md. : 1950) (161:5825)||1998|
B7 blockade prevents activation-induced cell death of thymocytes.
A18649 was used in flow cytometry to elucidate the role of B7 in thymic selection.
|Samoilova EB,Horton JL,Bassiri H,Zhang H,Linsley PS,Carding SR,Chen Y||International immunology (9:1663)||1997|