|Tested species reactivity||Dog, Mouse|
|Published species reactivity||Mouse, Not Applicable|
|Host / Isotype||Armenian hamster / IgG2|
|Immunogen||CD80-transfected CHO cell line|
|Storage buffer||PBS, pH 7.4|
|Contains||15mM sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||6 ug/ml|
|Functional Assay (FN)||Assay Dependent|
|Immunohistochemistry (Frozen) (IHC (F))||Assay-Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, the both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet; there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Not Applicable||Not Cited||
Transgenic TCR expression: comparison of single chain with full-length receptor constructs for T-cell function.
MA1-10287 was used in flow cytometry to investigate the use of three-domain single-chain T-cell receptors
|Zhang T,He X,Tsang TC,Harris DT||Cancer gene therapy (11:487)||2004|
Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions.
MA1-10287 was used in flow cytometry to generate and characterize mice deficient for CD37.
|Knobeloch KP,Wright MD,Ochsenbein AF,Liesenfeld O,Löhler J,Zinkernagel RM,Horak I,Orinska Z||Molecular and cellular biology (20:5363)||2000|