|Tested species reactivity||Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Rat / IgG2a|
|Storage buffer||PBS with 4-5mg/ml BSA|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1.0 ug/10^6 cells|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Miscellaneous PubMed (MISC)||See 2 publications below|
MA5-17936 targets CD80/LAB7 in FACS applications and shows reactivity with Mouse samples.
The MA5-17936 immunogen is mouse CD80.
CD80 is a member of the Ig superfamily and serves as the ligand for two T cell molecules, CD28 and CTLA4. Interactions between CD28 and CD80 on activated B cells result in enhanced T cell activation. CD80 is rapidly induced on the surface of in vitro activated B cells, with Epstein Barr Virus (EBV) transformed B cell lines, with Burkitts lymphoma cell lines, with freshly isolated follicular B lymphoma cells, T cells, and monocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Passive transfer of flt-3L-derived dendritic cells delays diabetes development in NOD mice and associates with early production of interleukin (IL)-4 and IL-10 in the spleen of recipient mice.
MA5-17936 was used in flow cytometry to assess the contribution of DC function in non-obese diabetic mice.
|Morin J,Faideau B,Gagnerault MC,Lepault F,Boitard C,Boudaly S||Clinical and experimental immunology (134:388)||2003|
Naive B lymphocytes undergo homeostatic proliferation in response to B cell deficit.
MA5-17936 was used in flow cytometry to investigate homeostatic B cell proliferation.
|Cabatingan MS,Schmidt MR,Sen R,Woodland RT||Journal of immunology (Baltimore, Md. : 1950) (169:6795)||2002|