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|Tested species reactivity||Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Rat / IgG2a|
|Immunogen||Mouse CD8 β|
|Storage buffer||PBS with 4-5mg/ml BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||0.1 ug/10^6 cells|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Flow Cytometry (Flow)||See 1 publications below|
MA5-17849 targets CD8b/LYT3 in FACS applications and shows reactivity with Mouse samples.
The MA5-17849 immunogen is mouse CD8 ß.
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Immunoglobulin and cytokine production from spleen lymphocytes is modulated in C57BL/6J mice by dietary cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid.
MA5-17849 was used in flow cytometry to study the effect of dietary cis-9, trans- and trans-0, cis-2 conjugated linoleic acid on immunoglobulin and cytokine production from spleen lymphocytes in C57BL/6J mice.
|Yamasaki M,Chujo H,Hirao A,Koyanagi N,Okamoto T,Tojo N,Oishi A,Iwata T,Yamauchi-Sato Y,Yamamoto T,Tsutsumi K,Tachibana H,Yamada K||The Journal of nutrition (133:784)||2003|
CD8 antigen beta chain; CD8 antigen beta-chain; Cd8b1; lymphocyte antigen 3; T-cell membrane glycoprotein Ly-3; T-cell surface glycoprotein CD8 beta chain; T-cell surface glycoprotein Lyt-3
Cd8b; Cd8b1; Ly-3; Ly-C; Lyt-3; Lyt3