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Staining of mouse splenocytes with Rat IgG2a Isotype Control FITC (top, open histogram) or Rat IgG2a Isotype Control PE (bottom, open histogram) and Anti-Mouse CD98 FITC (top, filled histogram) and 0.25 µg of Anti-Mouse CD98 PE (bottom, filled histogram, A16389). Total viable cells were used for analysis.
|Tested species reactivity||Mouse|
|Host / Isotype||Rat / IgG2a, kappa|
|Storage buffer||proprietary buffer|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
CD98 (4F2) is a type II transmembrane glycoprotein which serves as the heavy chain of the heterodimeric amino acid transporters (HATs). CD98, linked to various light chains by disulfide bond, is responsible for cell surface expression and basolateral localization of this transporter complex in polarized epithelial cells and also interacts with beta1 integrins and increases their affinity for ligand. Besides its roles in amino acid transport, CD98 is thus involved in cell fusion and activation. It is implicated in regulation of cellular differentiation, growth and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
4F2; 4F2 cell-surface antigen heavy chain; 4F2HC; 4T2HC; antigen identified by monoclonal antibodies 4F2; CD98; CD98 antigen; CD98 heavy chain; CD98HC; MDU1; NACAE; Solute carrier family 3 member 2; type II transmembrane protein
4F2; 4F2HC; AI314110; Cd98; Ly-10; Ly-m10; Ly10; Mdu1; Mgp-2hc; NACAE; Slc3a2