This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
MA5-17052 targets CDK2 in indirect ELISA, FACS, ICC, IHC, IF and WB applications and shows reactivity with Human and Mouse samples.
The MA5-17052 immunogen is purified recombinant fragment of human CDK2 expressed in E. Coli.
MA5-17052 detects CDK2 which has a predicted molecular weight of approximately 33.9kDa.
p33cdk2 associates with cyclin A in human cells. Kinase activity associated with cyclin A-cdc2 is found only in G2-phase. Cdk2 also complexes with cyclins E, D1, and D3. Cyclin E-cdk2 kinase is active in the G1- and S-phases of the cell cycle and is important (as does cyclin A-cdk2) for the progression from G1-to S-phase. The levels of cyclin A-cdk2 is maximal at the G1/S transition and both cdk2 and cyclin A are found associated with DNA in the initiation complex during replication. Rb protein acts as substrate for cdk2-cyclin E and/or cdk2-cyclin A in vivo. Cdk2 is activated and specifically localized to the nucleus during late G1-, S-, and G2-phase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cdc2-related protein kinase; CDC28; CDC2A; Cell division protein kinase 2; Cyclin-dependent kinase 2; EC 22.214.171.124; EC 126.96.36.199; kinase Cdc2; p33 protein kinase; p33CDK2
Gene Aliases: A630093N05Rik; CDK2; CDKN2; p33(CDK2)
Molecular Function: non-receptor serine/threonine protein kinase