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Proteintech
CDK2 Monoclonal Antibody (4E2E10)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
60312-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgM
Class
Monoclonal
Type
Antibody
Clone
4E2E10
Immunogen
CDK2 Fusion Protein Ag21310 (8-210 aa encoded by BC003065)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
150 µg
Purification
Caprylic acid precipitation
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: EKIGEGTYG VVYKARNKLT GEVVALKKIR LDTETEGVPS TAIREISLLK ELNHPNIVKL LDVIHTENKL YLVFEFLHQD LKKFMDASAL TGIPLPLIKS YLFQLLQGLA FCHSHRVLHR DLKPQNLLIN TEGAIKLADF GLARAFGVPV RTYTHEVVTL WYRAPEILLG CKYYSTAVDI WSLGCIFAEM VTRRALFPGD SEID (8-210 aa encoded by BC003065)
Target Information
CDK2/cyclinO is a member of the cyclin dependent protein kinase family complexed to CyclinO. CyclinO was used as a specific protein isoform name for the UNG gene which is localized exclusively in the nucleus. In addition, CyclinO was reported to shows significant uracil-DNA glycosylase activity. CDK2/cyclinO protein levels increase during G1 phase and the protein is turned over during the course of cell cycle. The levels of cyclin A-cdk2 is maximal at the G1/S transition and both cdk2 and cyclin A are found associated with DNA in the initiation complex during replication. Rb protein acts as substrate for cdk2-cyclin E and/or cdk2-cyclin A in vivo. Cdk2 is activated and specifically localized to the nucleus during late G1-, S-, and G2-phase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cdc2-related protein kinase; CDC28; CDC2A; CDK1; CDK2; cell division protein kinase 2; EC 2.7.11.22; EC 2.7.11.23; kinase Cdc2; MPF; p33 protein kinase; p33CDK2; p34 protein kinase; unnamed protein product
Gene Aliases: CDKN2; p33(CDK2)
UniProt ID: (Human) P24941
Entrez Gene ID: (Human) 1017
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
cyclin-dependent protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
protein domain specific binding
cyclin binding
histone kinase activity
cyclin-dependent protein kinase activity
protein serine kinase activity
G1/S transition of mitotic cell cycle
G2/M transition of mitotic cell cycle
DNA replication
chromatin remodeling
protein phosphorylation
centriole replication
signal transduction
Ras protein signal transduction
regulation of mitotic cell cycle
positive regulation of cell proliferation
peptidyl-serine phosphorylation
positive regulation of heterochromatin assembly
mitotic G1 DNA damage checkpoint
telomere maintenance in response to DNA damage
post-translational protein modification
positive regulation of DNA replication
centrosome duplication
meiotic cell cycle
cellular response to nitric oxide
cellular senescence
negative regulation of protein localization to chromatin
regulation of heterochromatin organization
regulation of anaphase-promoting complex-dependent catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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