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OriGene
CDK2 Monoclonal Antibody (OTI2D9), TrueMAB™
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
TA502935
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI2D9
Immunogen
Full length human recombinant protein of human CDK2 produced in HEK293T cell.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.78 mg/mL
Amount
78 µg
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
CDK2/cyclinO is a member of the cyclin dependent protein kinase family complexed to CyclinO. CyclinO was used as a specific protein isoform name for the UNG gene which is localized exclusively in the nucleus. In addition, CyclinO was reported to shows significant uracil-DNA glycosylase activity. CDK2/cyclinO protein levels increase during G1 phase and the protein is turned over during the course of cell cycle. The levels of cyclin A-cdk2 is maximal at the G1/S transition and both cdk2 and cyclin A are found associated with DNA in the initiation complex during replication. Rb protein acts as substrate for cdk2-cyclin E and/or cdk2-cyclin A in vivo. Cdk2 is activated and specifically localized to the nucleus during late G1-, S-, and G2-phase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cdc2-related protein kinase; CDC28; CDC2A; CDK1; CDK2; cell division protein kinase 2; cyclin dependent kinase 2-alpha; EC 2.7.11.22; EC 2.7.11.23; kinase Cdc2; MPF; p33 protein kinase; p33CDK2; p34 protein kinase; unnamed protein product
Gene Aliases: CDKN2; p33(CDK2)
UniProt ID: (Human) P24941
Entrez Gene ID: (Dog) 100855704, (Human) 1017, (Rat) 362817
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
cyclin-dependent protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
protein domain specific binding
cyclin binding
histone kinase activity
cyclin-dependent protein kinase activity
protein serine kinase activity
macromolecular complex binding
non-receptor serine/threonine protein kinase
G1/S transition of mitotic cell cycle
G2/M transition of mitotic cell cycle
DNA replication
chromatin remodeling
protein phosphorylation
centriole replication
signal transduction
Ras protein signal transduction
regulation of mitotic cell cycle
positive regulation of cell proliferation
peptidyl-serine phosphorylation
positive regulation of heterochromatin assembly
mitotic G1 DNA damage checkpoint
telomere maintenance in response to DNA damage
post-translational protein modification
positive regulation of DNA replication
centrosome duplication
meiotic cell cycle
cellular response to nitric oxide
cellular senescence
negative regulation of protein localization to chromatin
regulation of heterochromatin organization
regulation of anaphase-promoting complex-dependent catabolic process
negative regulation of transcription from RNA polymerase II promoter
lens development in camera-type eye
potassium ion transport
cellular response to DNA damage stimulus
response to xenobiotic stimulus
response to toxic substance
positive regulation of DNA-dependent DNA replication initiation
response to estradiol
cellular response to insulin stimulus
negative regulation of protein catabolic process
response to ethanol
positive regulation of transcription, DNA-templated
response to cadmium ion
response to cAMP
response to electrical stimulus
liver regeneration
positive regulation of meiotic cell cycle process involved in oocyte maturation
DNA synthesis involved in mitotic DNA replication
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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