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Invitrogen
This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
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MA5-17053 targets CDK5 in indirect ELISA, FACS, ICC, IHC, IF and WB applications and shows reactivity with Human, Non-human primate, and Rat samples.
The MA5-17053 immunogen is purified recombinant fragment of human CDK5 expressed in E. Coli.
MA5-17053 detects CDK5 which has a predicted molecular weight of approximately 35kDa.
CDK5 is a member of the Cyclin-Dependent Kinase family that is most abundant in the mammalian brain. Active form of CDK5, which has also been called neuronal cdc2-like kinase, is a heterodimer of CDK5 and a 25 kDa protein which is derived proteolytically from a 35 kDa brain and neuron-specific protein and is essential for the kinase activity of CDK5. CDK5 has emerged as a crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates a diverse list of substrates, implicating it in the regulation of a range of cellular processes - from adhesion and motility, to synaptic plasticity and drug addiction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CDK5-SV; Cell division protein kinase 5; CR6 protein kinase; Cyclin-dependent kinase 5; Cyclin-dependent-like kinase 5; protein kinase CDK5 splicing; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunit
Gene Aliases: AW048668; CDK5; CDKN5; Crk6; LIS7; PSSALRE
UniProt ID: (Human) Q00535, (Mouse) P49615, (Rat) Q03114
Entrez Gene ID: (Human) 1020, (Mouse) 12568, (Rat) 140908
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