This Antibody was verified by KnockOut to ensure that the antibody binds to the antigen stated. View Details
Suggested positive controls include HT29, MAD109, PC12 cells and brain tissue.
The protein encoded by this gene is a neuron-specific activator of cyclin-dependent kinase 5; the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.
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Protein Aliases: Cell division protein kinase 5; CR6 protein kinase; CRK6; cyclin-dependent kinase 5; cyclin-dependent kinase 5 activator 1; cyclin-dependent kinase 5 regulatory subunit 1; Cyclin-dependent-like kinase 5; neuronal CDK5 activator; protein kinase CDK5 splicing; regulatory partner for CDK5 kinase; Serine/threonine-protein kinase PSSALRE; tau protein kinase II 23kDa subunit; Tau protein kinase II catalytic subunit; TPKII catalytic subunit
Gene Aliases: AW048668; CDK5; CDKN5; Crk6; LIS7; PSSALRE