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Product Details
67503-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rabbit,
Rat
Published species
Not Applicable
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1A3A5
Immunogen
CDK5R1 Fusion Protein Ag13152
Conjugate
Form
Liquid
Concentration
500 µg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CDK5 activator 1; Cyclin-dependent kinase 5 activator 1; Cyclin-dependent kinase 5 regulatory subunit 1; cyclin-dependent kinase 5, regulatory subunit (p35) 1; cyclin-dependent kinase 5, regulatory subunit 1 (p35); neuronal CDK5 activator; p23; regulatory partner for CDK5 kinase; tau protein kinase II 23 kDa subunit; tau protein kinase II 23kDa subunit; TPKII regulatory subunit
Gene Aliases: CDK5P35; CDK5R; CDK5R1; D11Bwg0379e; NCK5A; p23; p25; p35; p35nck5a
UniProt ID: (Human) Q15078, (Rat) P61810, (Mouse) P61809
Entrez Gene ID: (Human) 8851, (Rabbit) 100351850, (Pig) 100113467, (Rat) 116671, (Mouse) 12569
protein kinase activity
cyclin-dependent protein serine/threonine kinase activity
calcium ion binding
protein binding
kinase activity
cyclin-dependent protein kinase 5 activator activity
protein kinase binding
protein serine/threonine kinase activator activity
cadherin binding
ephrin receptor binding
cytoskeletal protein binding
kinase activator
regulation of cyclin-dependent protein serine/threonine kinase activity
neuron migration
neuron cell-cell adhesion
G-protein coupled acetylcholine receptor signaling pathway
axon guidance
axonal fasciculation
brain development
cell proliferation
embryo development
regulation of macroautophagy
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
cerebellum development
superior olivary nucleus maturation
hippocampus development
layer formation in cerebral cortex
neuron differentiation
negative regulation of axon extension
neuron projection development
regulation of actin cytoskeleton organization
serine phosphorylation of STAT3 protein
ionotropic glutamate receptor signaling pathway
positive regulation of neuron apoptotic process
regulation of neuron differentiation
negative regulation of transcription, DNA-templated
ephrin receptor signaling pathway
rhythmic process
regulation of dendritic spine morphogenesis
regulation of microtubule cytoskeleton organization
positive regulation of cell cycle arrest
positive regulation of protein serine/threonine kinase activity
positive regulation of protein targeting to membrane
regulation of signal transduction by p53 class mediator
protein phosphorylation
cerebral cortex radially oriented cell migration
positive regulation of protein kinase activity
axon extension
regulation of cell cycle
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