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Bethyl Laboratories
CDK7 Recombinant Rabbit Monoclonal Antibody (BL-80-3D4)
Product Details
A700-006
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Expression System |
HEK293 cells |
Class |
Recombinant Monoclonal |
Type |
Antibody |
Clone |
BL-80-3D4 |
Immunogen |
Between 300 and 346 |
Conjugate |
Unconjugated |
Form |
liquid |
Concentration |
40 µg/mL |
Purification |
Ion-exchange chromatography |
Storage buffer |
BBS, pH 8.2, with 0.1% BSA |
Contains |
0.09% sodium azide |
Storage conditions |
4° C |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For ICC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections. For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 39 KDa protein kinase; CDK; CDK-activating kinase 1; Cell division protein kinase 7; Cyclin-dependent kinase 7; cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase); EC 2.7.11.22; EC 2.7.11.23; homolog of Xenopus MO15 Cdk-activating kinase; kinase subunit of CAK; OTTHUMP00000222032; OTTHUMP00000222033; p39 Mo15; serine/threonine kinase stk1; serine/threonine protein kinase 1; serine/threonine protein kinase MO15; Serine/threonine-protein kinase 1; TFIIH basal transcription factor complex kinase subunit
Gene Aliases: CAK; CAK1; CDK7; CDKN7; HCAK; MO15; p39MO15; STK1
UniProt ID: (Human) P50613
Entrez Gene ID: (Human) 1022
Molecular Function:
non-receptor serine/threonine protein kinase
regulation of cyclin-dependent protein serine/threonine kinase activity
G1/S transition of mitotic cell cycle
G2/M transition of mitotic cell cycle
transcription-coupled nucleotide-excision repair
nucleotide-excision repair, preincision complex assembly
transcription initiation from RNA polymerase I promoter
transcription elongation from RNA polymerase I promoter
termination of RNA polymerase I transcription
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
7-methylguanosine mRNA capping
protein phosphorylation
cell cycle arrest
cell proliferation
androgen receptor signaling pathway
snRNA transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cell division
transcription coactivator activity
protein kinase activity
protein serine/threonine kinase activity
cyclin-dependent protein serine/threonine kinase activity
protein binding
ATP binding
protein C-terminus binding
DNA-dependent ATPase activity
RNA polymerase II carboxy-terminal domain kinase activity
kinase activity
androgen receptor binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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