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OriGene
CDKL2 Monoclonal Antibody (OTI1D1), TrueMAB™
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FIGURE: 1 / 1
CDKL2 Antibody (TA805535) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CDKL2 (RC210780, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-CDKL2. Positive lysates LY418330 (100 µg) and LC418330 (20 µg) can be purchased separately from OriGene.
Product Details
TA805535
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI1D1
Immunogen
Human recombinant protein fragment corresponding to amino acids 291-493 of human CDKL2 produced in E.coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated by the MAP kinases ERK 1 and ERK 2. ERK proteins are regulated by dual phosphorylation at specific tyrosine and threonine sites mapping within a characteristic Thr-Glu-Tyr motif. The protein kinase p56 KKIAMRE is distantly related to the MAP kinase group of proteins and is closely related to p42 KKIALRE. KKIAMRE is predominantly expressed in testis, kidney, brain and lung. KKIAMRE contains the conserved MAP kinase dual phosphorylation motif in the sequence Thr-Asp-Tyr and is activated by treatment of cells by EGF. However, unlike other MAP kinases, the EGF-stimulated kinase activity does not require phosphorylation of KKIAMRE and KKIALRE in the Thr-Asp-Tyr motif.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDC2-related kinase; Cyclin-dependent kinase-like 2; cyclin-dependent kinase-like 2 (CDC2-related kinase); p56 KKIAMRE protein kinase; Protein kinase p56 KKIAMRE; serine/threonine protein kinase KKIAMRE; Serine/threonine-protein kinase KKIAMRE; testicular tissue protein Li 35
Gene Aliases: CDKL2; KKIAMRE; P56
UniProt ID: (Human) Q92772
Entrez Gene ID: (Human) 8999
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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