Cyclin-dependent kinase inhibitor 3 (CDKN3), also designated Cdk2-associated dual specificity phosphatase, cyclin-dependent kinase interactor 1 (CDI1), CIP2, KAP or KAP1, belongs to the protein-tyrosine phosphatase family. CDKN3, a cyclin-dependent kinase inhibitor, interacts and dephosphorylates Cdk2 kinase, which prevents Cdk2 kinase activation. CDKN3 is important in cell cycle regulation. It is a dual specificity phosphatase that is active toward substrates which contain phosphotyrosine or phosphoserine residues.
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Protein Aliases: CDI1; Cdk-associated protein phosphatase; CDK2-associated dual specificity phosphatase; CDK2-associated dual-specificity phosphatase; CDKN3; CIP2; cyclin-dependent kinase inhibitor; Cyclin-dependent kinase inhibitor 3; cyclin-dependent kinase interacting protein 2; Cyclin-dependent kinase interactor 1; Cyclin-dependent kinase-interacting protein 2; kinase associated phosphatase; Kinase-associated phosphatase
Gene Aliases: CDI1; CDKN3; CIP2; KAP; KAP1
UniProt ID: (Human) Q16667
Entrez Gene ID: (Human) 1033