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|Tested species reactivity||Human, Non-human primate|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Prokaryotic, recombinant protein corresponding to the 180 residue N-terminal region of the human CDX2 molecule.|
|Storage buffer||tissue culture supernatant|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:25-1:50|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-25822 detects CDX2 from human samples.
MA1-25822 has been successfully used in immunohistochemistry (paraffin) procedures. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 1mM EDTA buffer, p.H. 8.0 prior to immunostaining. A positive control for this product is colon cancer.
The MA1-25822 immunogen is a prokaryotic, recombinant protein corresponding to the 180 residue N-terminal region of the human CDX2 molecule.
CDX2 is a caudal type homeobox gene that encodes an intestine-specific transcription factor that is expressed early in intestinal development and may be involved in the regulation of proliferation and differentiation of intestinal epithelial cells. It is expressed in the nuclei of epithelial cells throughout the intestine, from duodenum to rectum. The CDX2 protein is expressed in primary and metastatic colorectal carcinomas and has also been demonstrated in the intestinal metaplasia of the stomach and intestinal-type gastric cancer, while it is not expressed in the normal gastric mucosa. Studies have shown that CDX2 is superior marker compared to CK20.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
caudal type homeo box transcription factor 2; caudal type homeobox transcription factor 2; caudal-type homeobox protein 2; CDX3; homeobox protein CDX-2