MA5-14494 targets CDX2 in WB, IHC (P), ICC/IF and FACS applications and shows reactivity with Human and Mouse samples.
The MA5-14494 immunogen is a synthetic peptide corresponding to residues near the N-terminus of human CDX2.
The caudal-related homeodomain protein2 (CDX2) is a transcription factor shown to play a role in the development of small and large intestine in mammals and in the differentiation of intestinal epithelial cells. It has been shown that CDX2 protein detection by IHC coorelates with RNA transcript levels. In studies using 745 cancers from many anatomic sites, colonic adenocarcinomas demonstrated strong staining in 90% of the cases, while adenocarcinomas of the stomach, esophagus and ovary showed extensive staining in only 30% of the cases. Stains of CDX2 and Villin are useful markers in differntial diagnosis of bladder adenocarcinoma and secondary colorectal adenocarcinoma.
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Protein Aliases: caudal type homeo box 2; caudal type homeo box transcription factor 2; caudal type homeobox transcription factor 2; Caudal-type homeobox protein 2; CDX-3; Homeobox protein CDX-2; homeobox protein miniCDX2
Gene Aliases: Cdx-2; CDX-3; CDX2; CDX2/AS; CDX3