|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:100|
|Western Blot (WB)||1:1000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 472-502 amino acids from the C-terminal region of human BMPR1B|
|Purification||Ammonium sulfate precipitation, Size-exclusion - Dialysis|
|Contains||0.09% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody is predicted to react with chicken and mouse based on sequence homology.
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: activin receptor-like kinase 6; ALK6; BMP type-1B receptor; BMPR-1B; bone morphogenetic protein receptor type IB; Bone morphogenetic protein receptor type-1B; bone morphogenetic protein receptor, type IB; CDw293; Serine(threonine) protein kinase; serine/threonine receptor kinase
Gene Aliases: ALK-6; ALK6; AMDD; BDA1D; BDA2; BMPR1B; CDw293
UniProt ID: (Human) O00238
Entrez Gene ID: (Human) 658
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