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|Tested species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Storage buffer||PBS, pH 7.4|
|Contains||15mM sodium azide|
|Storage Conditions||4° C, do not freeze|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||2-8 ug/ml|
|Immunocytochemistry (ICC)||20 ug/ml|
|Immunohistochemistry (Paraffin) (IHC (P))||Assay Dependent|
|Western Blot (WB)||Assay-Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody reacts with some tissue macrophages and carcinoma-expressed CEA.
The CD66 molecules are 180-200 kDa glycoproteins of carcinoembryonic antigen family. They are present on all blood granulocytes and some tissue macrophages, but are absent from other hematopoietic cells. The expression of CD66 increases significantly on granulocytes upon their activation. CD66a (BGP1, CEACAM1) and CD66d (CGM1, CEACAM3), as well as CEACAM2 and 4, are transmembrane proteins, whereas CD66c (CEAL, NCA, CEACAM6) and CD66e (CEA, CEACAM5), as well as CEACAM7 and 8, are anchored to the plasma membrane by C-terminal glycosylphosphatidylinositol (GPI) lipid moiety.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
antigen CD66; BGP-1; Biliary glycoprotein 1; Carcinoembryonic antigen; Carcinoembryonic antigen CGM1; carcinoembryonic antigen gene family member 1; Carcinoembryonic antigen-related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); Carcinoembryonic antigen-related cell adhesion molecule 3; Carcinoembryonic antigen-related cell adhesion molecule 5; Carcinoembryonic antigen-related cell adhesion molecule 6; carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen); CD66a; CD66a antigen; CD66c; CD66d; CD66d antigen; CD66e; CEA; CEACAM-1; CEACAM-3; CEACAM-5; CEACAM-6; CGM1; Cluster of Differentiation 66c; Meconium antigen 100; NCA; Non-specific crossreacting antigen; nonspecific cross-reacting antigen; Normal cross-reacting antigen; pan CEACAM
BGP; BGP1; BGPI; CD66c; CD66D; CD66e; CEA; CEACAM1; CEACAM3; CEACAM5; CEACAM6; CEAL; CGM1; NCA; W264; W282
G-protein coupled receptor cell adhesion molecule cytokine receptor defense/immunity protein hydrolase immunoglobulin receptor superfamily immunoglobulin superfamily cell adhesion molecule phosphatase protein phosphatase receptor kinase membrane-bound signaling molecule protein kinase signaling molecule transferase