This antibody recognizes native human CEACAM1, 5 protein expressed in transfected mammalian cells.
Over-expression of CEA/CEACAM5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker CEACAM1 expression is down-regulated in many tumors indicating a tumor-suppressive function. The anti-tumor effect may be due to inhibition of tumor angiogenesis, possibly by increased secretion of anti-angiogenic molecules from the cells. The function of CEA family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: antigen CD66; BGP-1; Biliary glycoprotein 1; Carcinoembryonic antigen; Carcinoembryonic antigen-related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); Carcinoembryonic antigen-related cell adhesion molecule 5; CD66a; CD66a antigen; CD66e; CEA; Meconium antigen 100; pan CEACAM; sCD66e; soluble CD66e
Gene Aliases: BGP; BGP1; BGPI; CD66e; CEA; CEACAM1; CEACAM5