CELSR3 is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.
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Protein Aliases: adhesion G protein-coupled receptor C3; anchor protein; Cadherin EGF LAG seven-pass G-type receptor 3; Cadherin family member 11; cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila); EGF-like protein 1; EGF-like-domain, multiple 1; Epidermal growth factor-like protein 1; Flamingo homolog 1; hFmi1; Megf3; Multiple EGF-like domains protein 2; multiple epidermal growth factor-like domains 2; Multiple epidermal growth factor-like domains protein 2
Gene Aliases: ADGRC3; CDHF11; CELSR3; EGFL1; flamingo; FMI1; HFMI1; KIAA0812; MEGF2; mKIAA0812; RESDA1