Recommended positive controls: HeLa (G2 phase).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitosis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease.
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Protein Aliases: AH antigen; cell-cycle-dependent 350K nuclear protein; CENF; CENP-F; CENP-F kinetochore protein; Centromere protein F; centromere protein F, 350/400ka (mitosin); centromere protein F, 350/400kDa (mitosin); hcp-1; Kinetochore protein CENPF; Mitosin; PRO1779; RP11-262H5.1
Gene Aliases: CENF; CENPF; CILD31; hcp-1; PRO1779; STROMS
UniProt ID: (Human) P49454
Entrez Gene ID: (Human) 1063