|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:100|
|Western Blot (WB)||1:2000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 751-780 amino acids from the central region of human CFH|
|Purification||Antigen affinity chromatography|
|Contains||0.09% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short concensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: adrenomedullin binding protein; age-related maculopathy susceptibility 1; AHUS1; AMBP1; ARMD4; ARMS1; beta-1-H-globulin; beta-1H; CFHL3; Complement factor H; complement factor H, isoform b; factor H; factor H-like 1; FH; FHL1; H factor 1; H factor 1 (complement); H factor 2 (complement); HF; HF1; HF2; HUS
Gene Aliases: AHUS1; AMBP1; ARMD4; ARMS1; CFH; CFHL3; FH; FHL1; HF; HF1; HF2; HUS
UniProt ID: (Human) P08603
Entrez Gene ID: (Human) 3075
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