MA1-90819 detects CFTR from human samples.
MA1-90819 has been successfully used in immunofluorescence and immunohistochemistry (paraffin tissue) applications. Staining of formalin fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 minutes followed by cooling at room temperature for 20 minutes. A suggested positive control for this product is pancreas.
The MA1-90819 immunogen is synthetic peptide (Human).
Cystic Fibrosis Transmembrane Regulator (CFTR) is composed of two membrane-spanning domains (MSD), two nucleotide-binding domains (NBD) and one R domain. It is structurally similar to multidrug resistance protein (Mdr1), and both are members of the superfamily of ATP binding cassette (ABC) transporters, also known as traffic ATPases, which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3,5 cyclic monophosphate (cAMP) activated chloride ion channel found in the apical membranes of epithelia within the pancreas, airway, intestine, bile duct, sweat gland and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ABC35; ABCC7; ATP-binding cassette sub-family C member 7; cAMP-dependent chloride channel; CF; CFTR; CFTR/MRP; Channel conductance-controlling ATPase; Cystic fibrosis transmembrane conductance regulator; cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); dJ760C5.1; MRP7; tcag7.78; TNR-CFTR
Gene Aliases: ABC35; ABCC7; CF; CFTR; CFTR/MRP; dJ760C5.1; MRP7; TNR-CFTR
UniProt ID: (Human) P13569
Entrez Gene ID: (Human) 1080