MA5-15579 targets CHD3 in FACS, IF, IHC, and WB applications and shows reactivity with Human and mouse samples.
The MA5-15579 immunogen is purified recombinant fragment of human CHD3 expressed in E. Coli.
MA5-15579 detects CHD3 which has a predicted molecular weight of approximately 226kDa.
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.
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Protein Aliases: ATP-dependent helicase CHD3; CHD-3; CHD3; Chromodomain-helicase-DNA-binding protein 3; hZFH; Mi-2 alpha; Mi-2 autoantigen 240 kDa protein; Mi-2a; Mi2-ALPHA; ZFH; Zinc finger helicase; zinc-finger helicase (Snf2-like)
Gene Aliases: 2600010P09Rik; AF020312; CHD3; Chd7; Mi-2a; Mi2-ALPHA; Prp7; Prp9-1; ZFH
UniProt ID: (Human) Q12873