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MA5-15579 targets CHD3 in indirect ELISA, FACS, IF, IHC, and WB applications and shows reactivity with Human and mouse samples.
The MA5-15579 immunogen is purified recombinant fragment of human CHD3 expressed in E. Coli.
MA5-15579 detects CHD3 which has a predicted molecular weight of approximately 226kDa.
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ATP-dependent helicase CHD3; CHD-3; Chromodomain-helicase-DNA-binding protein 3; hZFH; MGC40857; Mi 2a; Mi-2 alpha; Mi-2 autoantigen 240 kDa protein; Mi2 ALPHA; Mi2-alpha; Prp9 1; Zinc finger helicase; zinc-finger helicase (Snf2-like)
Gene Aliases: 2600010P09Rik; AF020312; CHD3; Chd7; Mi-2a; Mi2-ALPHA; Prp7; Prp9-1; ZFH
UniProt ID: (Human) Q12873