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Product Details
CF808543
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:2,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:150 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Mouse / IgG1 |
Class |
Monoclonal |
Type |
Antibody |
Clone |
OTI2E6 |
Immunogen |
Full length human recombinant protein of human CHMP5 produced in E.coli. |
Conjugate |
Unconjugated |
Form |
lyophilized |
Concentration |
1 mg/mL |
Purification |
Affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 8% trehalose |
Contains |
no preservative |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein family. These proteins are components of ESCRT-III, a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies. Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A, is required for both MVB formation and regulation of cell cycle progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: apoptosis-related protein PNAS-2; Charged multivesicular body protein 5; chromatin modifying protein 5; Chromatin-modifying protein 5; HGNC:26942; hVps60; SNF7 domain containing 2; SNF7 domain-containing protein 2; Vacuolar protein sorting-associated protein 60; Vps60
Gene Aliases: C9orf83; CGI-34; CHMP5; HSPC177; PNAS-114; PNAS-2; SNF7DC2; Vps60
UniProt ID: (Human) Q9NZZ3
Entrez Gene ID: (Human) 51510
Molecular Function:
membrane traffic protein
cell separation after cytokinesis
regulation of receptor recycling
nucleus organization
lysosome organization
mitotic metaphase plate congression
endosome to lysosome transport
regulation of centrosome duplication
protein transport
endosomal transport
viral life cycle
multivesicular body assembly
viral budding
multivesicular body sorting pathway
cell-cell adhesion
regulation of mitotic spindle assembly
ESCRT III complex disassembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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