Invitrogen

CHN1 Monoclonal Antibody (OTI3C6)

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CHN1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry was performed on paraffin-embedded human pancreas tissue. To expose target proteins, 10mM citric buffer, pH6.0, 100°C for 10min was used. Following antigen retrieval, tissues were probed with a CHN1 monoclonal antibody (Product # MA5-26053).

CHN1 Antibody in Western Blot (WB) — Western blot analysis of CHN1 in HEK293T cells in untransfected (Left lane) and transfected (Right lane) samples using 5 µg per lane. The samples were separated by SDS-PAGE and probed with CHN1 (Product # MA5-26053) monoclonal antibody.

Product Details

MA5-26053

Applications	Tested Dilution	Publications
Western Blot (WB)	1:1,000-1:2,000	-
Immunohistochemistry (Paraffin) (IHC (P))	1:150	-

Product Specifications
Species Reactivity	Dog, Human, Mouse, Non-human primate, Rat
Host/Isotype	Mouse / IgG1
Class	Monoclonal
Type	Antibody
Clone	OTI3C6
Immunogen	Full length human recombinant protein of CHN1 produced in HEK293T cell View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	1 mg/mL
Purification	Affinity Chromatography
Storage buffer	PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20° C, Avoid Freeze/Thaw Cycles
RRID	AB_2722992

Target Information

GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: A-chimaerin; a2-chimaerin; Alpha-chimerin; alpha1 chimaerin; alpha2 chimaerin; alpha3-chimerin; chimaerin; chimaerin 1; chimerin (chimaerin) 1; N-chimaerin; N-chimerin; NC; Rho GTPase-activating protein 2

Gene Aliases: 0610007I19Rik; 0710001E19Rik; 1700112L09Rik; 2900046J01Rik; AI413815; ARHGAP2; CHN; CHN1; DURS2; NC; RHOGAP2

UniProt ID: (Human) P15882, (Rat) P30337, (Mouse) Q91V57

Entrez Gene ID: (Dog) 478805, (Human) 1123, (Rat) 84030, (Mouse) 108699

Function(s)

motor neuron axon guidance positive regulation of signal transduction intracellular signal transduction positive regulation of GTPase activity ephrin receptor signaling pathway regulation of axonogenesis regulation of small GTPase mediated signal transduction signal transduction nervous system development regulation of GTPase activity

Process(es)

SH3/SH2 adaptor activity GTPase activator activity protein binding metal ion binding ephrin receptor binding phorbol ester receptor activity