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Product Details
CF810226
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI4B9
Immunogen
Full length human recombinant protein of human CHP produced in HEK293T cell.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: calcineurin B homolog; Calcineurin B homologous protein 1; Calcineurin B-like protein; calcineurin homologous protein; calcineurin-like EF hand protein 1; calcineurin-like EF-hand protein 1; calcium binding protein P22; Calcium-binding protein CHP; Calcium-binding protein p22; EF-hand Ca2+-binding protein p22; EF-hand calcium-binding domain-containing protein p22; p24; Sid 470; SLC9A1 binding protein
Gene Aliases: 1500003O03Rik; AA960066; AI046351; Cahp; CHP; CHP1; p22; p24; Sid470; Sid470p; SLC9A1BP; vac; Wrch2
UniProt ID: (Human) Q99653, (Rat) P61023, (Mouse) P61022
Entrez Gene ID: (Human) 11261, (Rat) 64152, (Mouse) 56398
microtubule bundle formation
negative regulation of protein phosphorylation
negative regulation of protein kinase activity
protein export from nucleus
negative regulation of phosphatase activity
calcium ion regulated exocytosis
calcium-mediated signaling
membrane docking
cytoplasmic microtubule organization
negative regulation of protein ubiquitination
negative regulation of protein autophosphorylation
negative regulation of NF-kappaB transcription factor activity
positive regulation of sodium:proton antiporter activity
negative regulation of protein import into nucleus
transcytosis
protein stabilization
positive regulation of protein transport
protein oligomerization
regulation of intracellular pH
positive regulation of protein glycosylation
membrane organization
membrane fusion
negative regulation of calcineurin-NFAT signaling cascade
cellular response to acidic pH
positive regulation of protein targeting to membrane
regulation of neuron death
transport
protein transport
potassium ion transport
small GTPase mediated signal transduction
hyaluronan catabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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