Muscarinic cholinergic receptor 2 (CHRM2) is an Acetylcholine Receptor has been suggested to function as a presynaptic autoreceptor that inhibits acetylcholine release. The M2 receptor has also been suggested to mediate smooth muscle contractility. Alzheimer's disease (AD) involves selective loss of M2 subtype receptors in cortical and hippocampal regions of the human brain. Increase in M2 receptor heterozygosity has been associated with depression in women. The M2 receptor has been reported to be expressed in various regions of the brain including the cerebellum, cerebral cortex, hippocampus, medulla, striatum, and thalamus, and in lung and prostate.
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Protein Aliases: 7TM receptor; acetylcholine receptor; acetylcholine receptor, muscarinic 2; AChR M2; cholinergic receptor; cholinergic receptor, muscarinic 2; cholinergic receptor, muscarinic 2, cardiac; cholinergic receptor, muscarinic 2, isoform a; FLJ43243; M2 muscarinic acetylcholine receptor; M2-mAChR; m2AChR; MGC120006; MGC120007; muscarinic acetylcholine receptor 2; Muscarinic acetylcholine receptor M2; muscarinic M2 receptor; muscarinic receptor m2
Gene Aliases: AChR-M2; Acm2; Chrm-2; CHRM2; HM2; M2
Molecular Function: G-protein coupled receptor