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Immunogen sequence: LRKLFTDLFD RKGYMFDYEY DWIGKQLPTP VGAVQQDPAL SSNREAHQHR DKMQQSKNQV VSSTNGELNT DDPTAGRSNA PITAPTEVEV MDETNCQKVL NMWCCCFFKR RKRKTIQRHK; Positive Samples: Mouse eye, Mouse brain, Rat heart; Cellular Location: Cytoplasm
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The casein kinase 1 (CK1) group consists of 12 kinases including CK1, TTBK (tau tubulin kinase), and VRK (vaccinia-related kinase) families. The receptor guanylate cyclase (RGC) group consists of 5 kinases similar in domain sequence to TKs (ANP, CYG).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Casein kinase I isoform gamma-3; CKI-gamma 3
Gene Aliases: 3300002K07Rik; C330049O21Rik; Csnk1g3
UniProt ID: (Mouse) Q8C4X2, (Rat) Q62763
Entrez Gene ID: (Mouse) 70425, (Rat) 64823
Molecular Function:
kinase
non-receptor serine/threonine protein kinase
protein kinase
transferase
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