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Invitrogen
CK2 alpha-2 Monoclonal Antibody (1E1)
Product Details
MA5-17062
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1E1
Immunogen
Purified recombinant fragment of human CSNK2A2 (amino acids: 194-350) expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2538533
Product Specific Information
MA5-17062 targets CSNK2A2 in FACS, indirect ELISA, and WB applications and shows reactivity with Human and Mouse samples.
The MA5-17062 immunogen is purified recombinant fragment of human CSNK2A2 (amino acids: 194-350) expressed in E. Coli.
MA5-17062 detects CSNK2A2 which has a predicted molecular weight of approximately 41.2kDa.
Target Information
Casein kinase II is a protein serine/threonine kinase that is thought to be present in all eukarotic cells, implying that it has fundamental cellular functions. The holoenzyme is a tetramer containing 2 alpha or alpha-prime subunits (or one of each) and 2 beta subunits. The function of beta subunits is unknown and the alpha subunit is the catalytic unit. CK2 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha'-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CK2 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the phosphorylation of Akt.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: casein kinase 2 alpha; casein kinase 2 alpha'; casein kinase 2, alpha prime polypeptide; Casein kinase II subunit alpha'; casein kinase II, alpha 2, polypeptide; CK II alpha'
Gene Aliases: 1110035J23Rik; C77789; CK2; CK2A2; CK2alpha'; CSNK2A1; CSNK2A2
UniProt ID: (Human) P19784, (Mouse) O54833
Entrez Gene ID: (Human) 1459, (Mouse) 13000, (Rat) 307641
transcription, DNA-templated
regulation of transcription, DNA-templated
protein folding
protein phosphorylation
apoptotic process
Wnt signaling pathway
mitotic spindle checkpoint
regulation of signal transduction by p53 class mediator
regulation of mitophagy
positive regulation of protein targeting to mitochondrion
cell cycle
phosphorylation
regulation of cell cycle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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