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Immunofluorescent analysis of CKR-2B showing staining in the cytoplasm of Jurkat cells. Jurkat cells were fixed in 4% paraformaldehyde at RT for 15 min and stained using a CKR-2B polyclonal antibody (Product # PA5-29027) diluted at 1:500. Blue: Hoechst 33342 staining. Scale bar = 10µm.
|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to a region within amino acids 1 and 69 of Human CKR-2B|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-29027 targets CKR-2B in IHC (P) applications and shows reactivity with Human samples.
The PA5-29027 immunogen is synthetic peptide corresponding to a region within amino acids 1 and 69 of Human CKR-2B.
This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
CC-CKR-2; CCR-2; CCR2A; CCR2B; CD192; chemokine (C-C motif) receptor 2; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1 receptor; MCP-1-R; monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor
CC-CKR-2; CCR-2; CCR2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1-R